罗怀容教授-博导
作者:  发布时间:16-12-30 08:22:17   浏览次数: 次   来源:


罗怀容,女,1975年出生于四川泸县,教授,中国科学院“百人计划”研究员,博士生导师。曾获得中国科学院百人计划、云南省首届高端科技人才和云南省百名海外高层次人才引进计划;主持过国家自然科学基金、中科院知识创新工程领域前沿项目、云南省重点项目等多个项目的研究;共发表SCI论文70多篇,获得授权发明专利3项。研究结果发表在Clin Pharmacol TherJ Gerontol A Biol Sci Med SciBr J Pharmacol Aging J Proteomics Exp Gerontol等重要杂志上。现任中国老年保健医学研究会老年健康与转化医学分会青委会副主任委员、中国老年学和老年医学学会抗衰老分会委员、中国老年保健医学研究会老年健康与转化医学分会委员,云南省生物化学与分子生物学学会理事,云南省药理学会理事,云南省植物学会理事,昆明市实验动物行业协会常务理事。

 

研究方向:

衰老与老年医学,离子通道生理功能,衰老相关疾病药物筛选研究

热忱欢迎有志于从事相关研究领域的同仁加盟,欢迎来本团队开展研究工作!

座机电话:0830-3160842;手机/微信号:18716110756E-mail: lhr@swmu.edu.cn

地址:西南医科大学忠山校区(四川省泸州市忠山路3319号)含光楼402 646000

学历及工作经历

       1994-1998 兰州大学生物学系,生物化学,学士

   1998-2003 中国科学院昆明动物研究所遗传资源与进化国家重点实验室,动物学专业(功能基因组方向),博士。导师:张亚平院士

2004-2007 美国堪萨斯大学医学中心博士后。导师:Yu-Jui Yvonne Wan教授

2007-2008 美国迈阿密大学医学院博士后。导师:Julio Licinio教授

2010.1-2010.3 美国哥伦比亚大学访问教授。合作者:杨建教授  

2013.11-2014.3 美国德克萨斯大学休斯顿健康科学中心访问教授。合作者:朱曦教授

2008-2016   中国科学院昆明植物研究所植物化学与西部植物资源持续利用国家重点实验室,研究员,博士生导师

2016-至今   西南医科大学药学院,教授,博士生导师

部分代表论文(均为第一或通讯作者):

  1. Zheng SQ, Huang XB, Xing TK, Ding AJ, Wu GS, Luo HR*. Chlorogenic acid extends the lifespan of Caenorhabditis elegans via insulin/IGF-1 signaling pathway. J Gerontol A Biol Sci Med Sci. 2017;72(4):464-472.

  2. Wan QL, Shi X, Liu J, Ding AJ, Pu YZ, Li Z, Wu GS*, Luo HR*. Metabolomic signature associated with reproduction-regulated aging in Caenorhabditis elegans. Aging-US. 2017; 9(2): 447-474.

  3. Pu YZ, Wan QL, Ding AJ, Luo HR*, Wu GS*. Quantitative proteomics analysis of Caenorhabditis elegans upon germ cell loss. J Proteomics. 2017; 156: 85-93.

  4. Ding AJ, Wu GS, Tang B, Hong X, Zhu MX, Luo HR*. Benzimidazole derivative M084 extends the lifespan of Caenorhabditis elegans in a DAF-16/FOXO-dependent way. Mol Cell Biochem. 2017; 426(1-2): 101-109.

  5. Huang XB, Mu XH, Wan QL, He XM, Wu GS, Luo HR*. Aspirin increases metabolism through germline signalling to extend the lifespan of Caenorhabditis elegans. PLoS One. 2017;12(9):e0184027.

  6. Yang J, Huang XB, Wan QL, Ding AJ, Yang ZL, Qiu MH, Sun HY, Qi SH, Luo HR*. Otophylloside B protects against Aβ toxicity in Caenorhabditis elegans models of Alzheimer's disease. Nat Prod Bioprospect. 2017;7(2):207-214.

  7. Ding AJ, Zheng SQ, Huang XB, Xing TK, Wu GS, Sun HY, Qi SH, Luo HR*. Current perspective in the discovery of anti-aging agents from natural products. Nat Prod Bioprospect. 2017; 7(5): 335-404.

  8. Tang H, Wu GS, Xie J, He X, Deng K, Wang H, Xu F*, Luo HR*. Brain-wide map of projections from mice ventral subiculum. Neurosci Lett. 2016; 629: 171-9.

  9. 姜方洁,付玉,吴桂生,杨丽萍,唐贺,邓科,林万华,罗怀容*。慢性应激诱导小鼠杏仁核基底外侧核theta波段下调介导焦虑反应。广西师范大学学报. 2016; 34(1):162-167

  10. Yang LP, Jiang FJ, Wu GS, Deng K, Wen M, Zhou X, Hong X, Zhu MX, Luo HR*. Acute treatment with a novel TRPC4/C5 channel inhibitor produces antidepressant and anxiolytic-like effects in mice. PLoS One. 2015; 10(8):e0136255.

  11. Zhu Y, Lu Y, Qu C, Miller M, Tian J, Thakura DP, Zhu J, Deng Z, Hu X, Wu M, McManus OB, Li M, Hong X*, Zhu MX*, Luo HR*. Identification and optimization of 2-aminobenzimidazole derivatives as novel inhibitors of TRPC4 and TRPC5 channels. Br J Pharmacol. 2015; 172(14):3495-509.

  12. Yang J, Wan QL, Mu QZ, Wu CF, Ding AJ, Yang ZL, Qiu MH, Luo HR*. The lifespan-promoting effect of otophylloside B in Caenorhabditis elegans. Nat Prod Bioprospect. 2015; 5(4):177-83.

  13. Yuan XX, Yang LP, Yang ZL, Xiao WL*, Sun HD, Wu GS, Luo HR*. Effect of nigranoic acid on Ca2+ influx and its downstream signal mechanism in NGF-differentiated PC12 cells. J Ethnopharmacol. 2014; 153(3): 725-731.

  14. Wan QL, Zheng SQ, Wu GS, Luo HR*. Aspirin extends the lifespan of Caenorhabditis elegans via AMPK and DAF-16/FOXO in dietary restriction pathway. Exp Gerontol. 2013; 48(5): 499-506.

  15. Zheng SQ, Ding AJ, Li GP, Wu GS, Luo HR*. Drug absorption efficiency in Caenorhbditis elegans delivered by different methods. PLoS One. 2013; 8(2): e56877.

  16. Zhu J, Wu CF, Li X, Wu GS, Xie S, Hu QN, Deng Z, Zhu MX*, Luo HR*, Hong X*. Synthesis, biological evaluation and molecular modeling of substituted 2-aminobenzimidazoles as novel inhibitors of acetylcholinesterase and butyrylcholinesterase. Bioorg Med Chem. 2013; 21(14):4218-24.

  17. Zhang SS, Ma QY, Zou XS, Dai HF, Huang SZ, Luo Y, Yu ZF, Luo HR*, Zhao YX*. Chemical constituents from the Fungus Amauroderma amoiensis and their in vitro acetylcholinesterase inhibitory activities. Planta Med. 2013; 79(1): 87-91.

  18. Wang WG, Wu ZY, Chen R, Li HZ, Li HM, Li YD, Li RT*, Luo HR*. Pierisformotoxins A–D, polyesterified grayanane diterpenoids from Pieris formosa and their cAMP-decreasing activities. Chem Biodivers. 2013; 10(6):1061-71.

  19. Luo HR, Wu GS, Pakstis AJ, Tong L, Oota H, Kidd KK, Zhang YP. Origin and dispersal of atypical aldehyde dehydrogenase ALDH2*487Lys. Gene. 2009; 435: 96–103.

  20. Luo HR, Wu GS, Dong C, Arcos-Burgos M, Ribeiro L, Licinio J, Wong ML. Association of PDE11A global haplotype with major depression and antidepressant drug response. Neuropsychiatr Dis Treat. 2009; 5: 163-70.

  21. Luo HR, Poland RE, Lin KM, Wan YJ. Genetic polymorphism of cytochrome P450 2C19 in Mexican Americans: a cross-ethnic comparative study. Clin Pharmacol Ther. 2006; 80(1): 33-40.

  22. Luo HR, Wan YJ. Polymorphisms of genes encoding phase I enzymes in Mexican Americans-an ethnic comparison study. Curr Pharmacogenomics. 2006; 4(4): 345-53.

  23. Luo HR, Konishi T, Tsuang J, Wan YJ. Comparison of alcohol drinking behaviors and associated problems between benders and nonbenders in Mexican Americans who drink excessively. Addict Disord Their Treat. 2006; 5(3): 121-27.

  24. Luo HR, Gaedigk A, Aloumanis V, Wan YJ. Identification of CYP2D6 impaired functional alleles in Mexican Americans. Eur J Clin Pharmacol. 2005; 61(11): 797-802.

  25. Luo HR, Hou ZF, Wu J, Zhang YP, Wan YJ. Evolution of the DRD2 gene haplotype and its association with alcoholism in Mexican Americans. Alcohol. 2005; 36(2): 117-25.

  26. Luo HR, Israel Y, Tu GC, Eriksson CJP, Zhang YP. Genetic polymorphism of aldehyde dehydrogenase in Chinese: gender, age, culture and genotypes of ALDH2. Biochem Genet. 2005; 43 (5/6): 223-7.

  27. Luo HR, Aloumanis V, Lin KM, Gurwitz D, Wan YJ. Polymorphisms of CYP2C19 and CYP2D6 in Israeli ethnic groups. Mol Diagn Ther. 2004; 4(6): 395-401.

  28. Zhang YW#, Luo HR#, Ryder OA, Zhang YP. Evolution of the tandem repeats in thymidylate synthase enhancer region (TSER) in primates. Gene. 2004; 338(1): 47-54.

  29. Luo HR, Lü XM, Yao YG, Horie N, Takeishi K, Jorde LB, Zhang YP. Length polymorphism of thymidylate synthase regulatory region in Chinese populations and evolution of the novel alleles. Biochem Genet. 2002; 40(1-2): 41-51.

  30. Luo HR, Tu GC, Zhang YP. Detection of usual and atypical aldehyde dehydrogenase alleles by mismatch amplification mutation assay. Clin Chem Lab Med. 2001; 39(12): 1195-7.

    授权发明专利:

  31. 罗怀容,洪学传,朱曦,朱进妹,吴桂生,邓子新,朱颖旻,陆云刚,邓科,瞿春容。吡唑并嘧啶类化合物及其药物组合物和其在制药中的应用。授权号:ZL201310666552.1

  32. 罗怀容,洪学传,邓子新,吴桂生,杨丽萍,朱进妹,刘磊。苯并咪唑及其衍生物,其药物组合物及其在制备抗抑郁药物中的应用。授权号:ZL201210512505.7

  33. 邱明华,罗怀容,孙赟,周琳,胡映开,吴桂生。甾体生物碱化合物,其药物组合物及其制备方法和应用。授权号:ZL201110235562.0

    主持科研项目:

  34. 2017.1-2020.12 国家自然科学基金面上项目秀丽隐杆线虫生殖系统调控寿命的机制研究,资助经费70万元,批准号:81671405

  35. 2017.1-2019.12 泸州市科技局重点项目,中药抗衰老活性筛选及作用机制研究,资助经费30万元,批准号:2016LZXNYD-Z05

  36. 2014.10-2016.9 云南省重点新产品开发计划项目,抗抑郁症化学1类新药M084口服制剂的临床前预研究,资助经费80万元,批准号:2014BC011

  37. 2014.1-2017.12 国家自然科学基金面上项目,阿司匹林延缓秀丽线虫衰老的作用及机制研究,资助经费70万元,批准号:81370453

  38. 2013.10-2016.9云南省应用基础研究重点项目,阿司匹林抗衰老作用机制,资助经费40万元,批准号:2013FA045

  39. 2012.2-2015.1 云南省委组织部,神经系统药物研发,资助经费100万元。

  40. 2008.12-2012.12 云南省科学技术厅,云南天然药物抗神经精神疾病的分子机制研究,资助经费240万元,批准号:20080A007

  41. 2008.11-2012.12 中国科学院知识创新工程领域前沿项目,天然药物活性筛选与作用机制研究,资助经费300万元,批准号:2009312D11022

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