林秀坤教授-博导
作者:  发布时间:17-02-23 09:47:18   浏览次数: 次   来源:


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林秀坤、男、山东沂南,教授、博士生导师、中国科学院百人计划。

主要工作经历 1996获中国医学科学院、中国协和医科大学博士学位;1996-2002美国耶鲁大学作为博士后助理教授从事抗肿瘤机理研究, 2003年回国作为中国科学院百人计划,在海洋研究所任研究员。2016年进入西南医科大学。参入编写英文专著多部获得中国国内外发明专利18项。发表SCI论文近百篇余篇。现承担国家自然科学基金课题、国家创新药物重大专项课题等多项国家级研究课题。

科研方向:抗肿瘤药物的发现与作用机制

科研成果:发现了多种有开发前景的抗肿瘤先导药物,部分药物的研发进入临床研究;阐明了多种肿瘤相关基因的调控机制,发表SCI论文近百篇,在多肽、RNA抗肿瘤药物的研发方面处于国际先进水平。

社会兼职:中国药理学会肿瘤药理专业委员会常务委员;中国抗癌协会抗癌药物专业委员会常务委员;中国药学会生化与生物技术药物委员会委员,美国肿瘤学会会员, 美国耶鲁大学医学院客座教授。药学学报、 中国海洋药物以及美国SCI杂志Recent Patents of Anticancer Drug  Discovery 等杂志编委。

Email: xiukunlin@126.com

 

主持课题

 

1、国家自然科学基金面上项目,文蛤多肽靶向微管蛋白抑制肺癌生长的分子机制2015/01-2019/12

2、国家自然科学基金面上项目,Granulin A与ENO1的相互作用及其抑制肿瘤生长和转移的分子机制研究2017/01-2019/12

3  国家新药创制g重大转项抗肿瘤新药海鞘多肽的临床前研究,2013/01-2016/12

4  四川省科技厅国际合作项目,纳米RNA、多肽的制备及抗肿瘤作用,2017/01-2020/12

 

代表论文 *通讯作者)

1.Tian Y, Xu H, Farooq AA, Nie B, Chen X, Su S, Yuan R, Qiao G, Li CLin X *.Maslinic acid induces autophagy by down-regulating HSPA8 in pancreatic cancer cells.Phytother Res. 2018 Mar 8. doi: 10.1002/ptr.6064. [Epub ahead of print]. IF:3.2

2.Chen X, Xu H, Wu N, Liu X, Qiao G, Su S, Tian Y, Yuan R, Li C, Liu X, Lin X*. Interaction between granulin A and enolase 1 attenuates the migration and invasion of human hepatoma cells.Oncotarget. 2017 May 2;8(18):30305-30316. doi: 10.18632/oncotarget.16328. IF: 5.1

3. Liu M, Zhao G, Cao S, Zhang Y, Li X, Lin X*. Development of Certain Protein Kinase Inhibitors with the Components from Traditional Chinese Medicine. Front Pharmacol. 2017 Jan 9;7:523. doi: 10.3389/fphar.2016.00523. eCollection IF:4.1

4.Yuan R1, Xu H1, Liu X, Tian Y, Li C, Chen X, Su S, Perelshtein I, Gedanken A, Lin X*. Zinc-doped copper oxide nanocomposites inhibit the growth of human cancer cells through reactive oxygen species-mediated NF-κB activations. ACS Appl Mater Interfaces. 2016 Oct 28. [Epub ahead of print] IF:7.145

5.Chen X, Xu H, Li B, Wang F, Chen X, Kong D, Lin X*. Preparation and Antitumor Activity of CS5931, A Novel Polypeptide from Sea Squirt Ciona Savignyi. Marine Drugs. 2016 Mar 21;14(3). pii: E47 IF:3.345

Irena Rytblat, Ning Wu#, Huangli Xu, Aharon Gedanken* , Xiukun Lin*. In vitro studies of polyethyleneimine coated miRNA microspheres as anticancer agents. Research Article. Nano Research, pp 1-9. First online: 08 April 2016 IF:8.893

6.Zhu S, Wang J, Xie B, Luo Z*, Lin X*, Liao DJ*.Culture at a Higher Temperature Mildly Inhibits Cancer Cell Growth but Enhances Chemotherapeutic Effects by Inhibiting Cell-Cell Collaboration. PLoS One, 2015 Oct 23;10(10):e0137042. doi: 10.1371/journal.pone.0137042. eCollection 2015 IF:3.5

7.Wu N, Liu J, Zhao X, Yan Z, Jiang B, Wang L, Cao S, Shi D, Lin X*.Cardamonin induces apoptosis by suppressing STAT3 signaling pathway in glioblastoma stem cells. Tumor Biol, 2015, 36 (12): 9667-9676 IF:3.6

8.Xu H, Zhao X, Liu X, Xu P, Zhang K, Lin X*.Antitumor effects of traditional Chinese medicine targeting the cellular apoptotic pathway. Drug Design, Development and Therapy. 2015, 9: 2735-2744. IF:3.0

9.Lin X, Farooqi AA, Ismail M.Recent progress in fungus-derived bioactive agents for targeting of signaling machinery in cancer cells. Drug Design, Development and Therapy, 2015, 9 1797–1804. IF:3.0

Liu J, Ma L, Wu N, Liu G, Zheng L*, Lin X*.Aplysin Sensitizes Cancer Cells to TRAIL by Suppressing P38 MAPK/Survivin Pathway. Mar Drugs. Sep 2014; 12(9): 5072–5088. Published online Sep 25, 2014.  doi:  10.3390/md12095072 IF:3.5

Liu J, Wu N, Ma L, Liu M, Liu G, Zhang Y, Lin X.* Oleanolic Acid Suppresses Aerobic Glycolysis in Cancer Cells by Switching Pyruvate Kinase Type M Isoforms. PLoS One. 2014,;9(3):e91606. doi: 10.1371/journal.pone.0091606. eCollection 2014.IF:3.5

Liu J, Zheng L, Ma L, Wang B, Zhao Y, Wu N, Liu G, Lin X*.Oleanolic acid inhibits proliferation and invasiveness of Kras-transformed cells via autophagy. J Nutr Biochem. 2014 Jul 31. pii: S0955-2863(14)00147-8. doi: 10.1016 IF 4.6

Liu G, Liu M, Wei J, Lin X*.CS5931, a novel polypeptide in Ciona savignyi, represses angiogenesis via inhibiting vascular endothelial growth factor (VEGF) and matrix metalloproteinases (MMPs). Marine Drugs. 2014 Mar 13;12(3):1530-44. doi: 10.3390/md12031530. IF: 3.8

Liu J, Zheng L, Wu N, Ma L, Zhong J, Liu G, Lin X*. Oleanolic Acid Induces Metabolic Adaptation in Cancer Cells by Activating the AMP-Activated Protein Kinase Pathway. J Agric Food Chem. 2014 Jun 6. [Epub ahead of print] IF: 3.1

Liu M, Wang G, Xiao L, Xu X, Liu X, Xu P, Lin X*. Bis(2,3-dibromo-4,5-dihydroxybenzyl) Ether, a Marine Algae Derived Bromophenol, Inhibits the Growth of Botrytis cinerea and Interacts with DNA Molecules.Mar Drugs. 2014 Jun 27;12(7):3838-51. doi: 10.3390/md12073838. IF: 3.8

N Wu, Lin X*, X Zhao, et al., MiR-125b acts as an oncogene inglioblastoma cells and inhibits cell apoptosis through p53 and p38MAPK-independentpathways. British J. Cancer, DOI:10.1038/bjc.2013.672, IF: 5.6

Zhao J, Wei J, Liu M, Xiao L, Wu N, Liu G, Huang H, Zhang Y, Zheng L, Lin X* Cloning, characterization and expression of a cDNA encoding a granulin-t   polypeptide in Ciona savignyi.Biochimie. 2013 Aug;95(8):1611-9. IF: 3.5

Zheng L, Lin X*, Wu N, Liu M, Zheng Y, Sheng J, Ji X, Sun M. Targeting cellular apoptotic pathway with peptides from marine organisms Biochim Biophys Acta. 2013 Aug;1836(1):42-8, IF: 9.38

Liu M, Zhao X, Zhao J, Xiao L, Liu H, Wang C, Cheng L, Wu N, Lin X*.Induction of apoptosis, G₀/G₁ phase arrest and microtubule disassembly in K562 leukemia cells by Mere15, a novel polypeptide from Meretrix meretrix Linnaeus. Mar Drugs. 2012 Nov 21;10(11):2596-607. IF: 3.8

Wu N, Xiao L, Zhao X, Zhao J, Wang J, Wang F, Cao S, Lin X*.miR-125b regulates the proliferation of glioblastoma stem cells by targeting E2F2.FEBS Lett. 2012 Nov 2;586(21):3831-9. IF: 3.8

 

论著

1.Bioactive Compounds from Marine Foods: Plant and Animal Sources2013, pp57-67, Wiley blachwell Press

2. Handbook of Anticancer Drugs from Marine rigin》, 2015, pp529-545, Edited by Springer International publishing, Switzland



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