高蝶博士
作者:  发布时间:18-03-19 23:11:13   浏览次数: 次   来源:


高蝶1989-),女,重庆市沙坪坝人,博士,讲师,在西南医科大学药学院药物分析团队工作。在科学研究方面,主要从事天然药物活性成分分析、活性成分筛选、药物代谢分析、样品前处理等领域的研究。具体的研究方向为:(1) II型糖尿病中药的活性成分及药理作用研究;(3) 样品前处理方法的研究(分子印迹、固相微萃取);(4) 药物的活体代谢分析;(5) 荧光阵列传感器用于疾病标志物、环境污染物及中药痕量成分的检测。5年在Talanta, Journal of Agricultural and Food Chemistry, Journal of Ethnopharmacology, Journal of Separation Science等杂志上共发表SCI论文10余篇,其中,以第一作者或通讯作者发表SCI论文7篇。近5年来作为主要成员参与4项国家级科研项目及1项省市级项目。

联系方式:

手机/微信号:19982598003E-mail: gaodie_1203@126.com

地址:西南医科大学忠山校区(泸州市忠山路3319号)含光楼210

学历及工作经历:

2008-2012重庆大学药学系,药学,学士导师:夏之宁

2012-2017重庆大学,化学工程与技术,博士导师:夏之宁

2017-至今西南医科大学药学院,讲师

代表性论文:

(1) Die Gao*, Dandan Wang, Qifeng Fu, Lujun Wang, Kailian Zhang, Fengqing Yang, Zhining Xia*, Preparation and evaluation of magnetic molecularly imprinted polymers for the specific enrichment of phloridzin, Talanta, 2018,178, 299-307.

(2) Die Gao*, Qifeng Fu, Lujun Wang, Dandan Wang, Kailian Zhang, Fengqing Yang, Zhining Xia*, Molecularly imprinted polymers for the selective extraction of tiliroside from the flowers of Edgeworthia gardneri (wall.) Meisn, Journal of Separation Science, 2017, 40, 2629-2637.

(3) Die Gao, Dandan Wang, Qian Zhang, Fengqing Yang, Zingning Xia*, Qihui Zhang*, Chunsu Yuan, In Vivo selective capture and rapid identification of luteolin and its metabolites in rat livers by molecularly imprinted solid-phase Mmicroextraction, Journal of Agricultural and Food Chemistry, 2017, 65, 1158-1166.

(4) Die Gao, Fengqing Yang, Zingning Xia*, Qihui Zhang*, Molecularly imprinted polymer for the selective extraction of luteolin from Chrysanthemum morifolium Ramat, Journal of separation science, 2016, 39, 3002-3010.

(5) Die Gao, Yonglan Zhang, FengqingYang, Fan Li, Qihui Zhang, Zhining Xia*, The flower of Edgeworthia gardneri (wall.) Meisn. suppresses adipogenesis through modulation of the AMPK pathway in 3T3-L1 adipocytes, Journal of Ethnopharmacology, 2016, 191, 379-386.

(6) Die Gao, Yonglan Zhang, FengqingYang, Yexin Lin, Qihui Zhang, Zhining Xia*, In vitro screening and evaluation of 37 traditional Chinese medicines for their potential to activate peroxisome proliferator-activated receptors-gamma, Pharmacognosy Magazine, 2016, 12,120-127.

(7) Die Gao, Yonglan Zhang, Pan Xu, Yexin Lin, Fengqing Yang, Jianhui Liu, Haiwen Zhu,
Zhining Xia*, In vitro evaluation of dual agonists for PPARgamma/beta from the flower of Edgeworthia gardneri (wall.) Meisn, Journal of Ethnopharmacology, 2015, 162, 14-19.

(8) Dandan Wang, Die Gao, Wanjun Xu, Fan Li, Manni Yin, Qifeng Fu, Zhining Xia* ,Magnetic molecularly imprinted polymer for the selective extraction of hesperetin from the dried pericarp of Citrus reticulata Blanco, Talanta (Accepted).

(9) Qian Zhang, Yali Wang, Die Gao, Liang Cai, Yiyao Yang, Yuanjia Hu, Fengqing Yang*, Hua Chen, Zhining Xia, Comparing coagulation activity of Selaginella tamariscina before and after stir-frying process and determining the possible active constituents based on compositional variation, Pharmaceutical Biology, 2018, 56, 67-75.

(10) Fan Li, Weili Wei, Die Gao, Zhining Xia*, The adsorption behavior and mechanism of perfluorochemicals on oxidized fluorinated graphene sheets supported on silica, Analytical Methods, 2017, 9, 6645-6652.

(11) Qifeng Fu, Kailian Zhang, Die Gao, Lujun Wang, Fengqing Yang, Yao Liu, Zhining Xia*, Escherichia coli adhesive coating as a chiral stationary phase for open tubular capillary electrochromatography enantioseparation, Analytica Chimica Acta, 2017, 969, 63-71.

(12) Lujun Wang, Die Gao, Zelong Xu, Fengqing Yang, Zhining Xia*, Chemical Constituents of Pouzolzia zeylanica with PPAR gamma and PPAR beta Activities, Chemistry of Natural Compounds, 2015, 51, 1157-1159.

(13) Zelong Xu, Fengqing Yang, Lujun Wang, Jing Lu, Die Gao, Weihua Huang, Zhining Xia*, A New gamma-Pyrone from Ampelocissus artemisiifolia, Chemistry of Natural Compounds, 2014,50, 982-984.

(14) 朱海雯,高蝶,张永兰,张起辉,夏之宁*,藏药绿萝花的化学成分研究[J],中国药房,27 (2016), 4293-4296

参与的科研项目:

1. 国家自然科学基金面上项目,21275169,磁性纳米微球-细胞亲和毛细管电色谱及其应用研究,2013/01-2016/1280万元,已结题,主持。

2. 国家自然科学基金青年基金项目,81202886,血小板电色谱法筛选典型活血化瘀中药活性成分研究,2013/01-2015/1223万元,已结题,主持。

3. 国家自然科学基金面上项目,21175159,细菌选择介质手性毛细管电泳及其应用研究,2012/01-2015/1260万元,已结题,参加。

4. 国际科技合作计划项目(科技部),2010DFA32680,治疗糖尿病中药有效成分筛选与系统现代化研究,2010/05-2013/0478万元,已结题,参加。

5. 四川省教育厅重点项目,18ZA0527,智能响应多模式液相色谱固定相研究,2018/01-2020/122万元,在研,第一主研。

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