乔淦，博士。出生于1990年09月，毕业于首都医科大学，药理学专业。现为厅市共建中枢系统神经药物四川省重点实验室成员。任四川省肿瘤康复委员会，常委；中国药理学会肿瘤药物专委会，会员；中国抗癌协会抗肿瘤药物专委会，会员。

主要研究方向：

• 基于PGRN/granulins稳态改变与FTLD发生发展的分子机制研究；

• 大分子抗肿瘤药物的筛选及机制研究；

• 心肌病发生发展的机制研究

教育经历：

• 2013.09-2016.07 青岛科技大学，轻工技术与工程专业，工学硕士；

• 2016.09-2019.07 首都医科大学，药理学，博士研究生。

部分代表论文：

1. Chen, Xiaoliang, Huanli Xu, Ning Wu, Xiujun Liu, Gan Qiao, Shuonan Su, Ye Tian, Ru Yuan, Cong Li, Xiaohui Liu, and Xiukun Lin. 2017. “Interaction between Granulin A and Enolase 1 Attenuates the Migration and Invasion of Human Hepatoma Cells.” Oncotarget 8(18):30305–16. doi: 10.18632/oncotarget.16328.

2. Chen, Xiaoliang, Lili Yin, Gan Qiao, Yanhua Li, Baoyuan Li, Yunfeng Bai, and Feng Feng. 2020. “Inhibition of Rac1 Reverses Enzalutamide Resistance in Castration-Resistant Prostate Cancer.” Oncology Letters 20(3):2997–3005. doi: 10.3892/ol.2020.11823.

3. Li, Cong, Huanli Xu, Xiaoliang Chen, Jijun Chen, Xiao Li, Gan Qiao, Ye Tian, Ru Yuan, Shuonan Su, Xiaohui Liu, and Xiukun Lin. 2019. “Aqueous Extract of Clove Inhibits Tumor Growth by Inducing Autophagy through AMPK/ULK Pathway.” Phytotherapy Research 33(7):1794–1804. doi: 10.1002/ptr.6367.

4. Li, Xiao, Huanli Xu, Cong Li, Gan Qiao, Ammad Ahmad Farooqi, Aharon Gedanken, Xiaohui Liu, and Xiukun Lin. 2019. “Zinc-Doped Copper Oxide Nanocomposites Inhibit the Growth of Pancreatic Cancer by Inducing Autophagy Through AMPK/MTOR Pathway.” Frontiers in Pharmacology 10:319. doi: 10.3389/fphar.2019.00319.

5. Qiao, Gan, Kangping Bi, Junhong Liu, Shousong Cao, Minghua Liu, Milica Pešić, and Xiukun Lin. 2021. “Protein Kinases as Targets for Developing Anticancer Agents from Marine Organisms.” Biochimica et Biophysica Acta (BBA) - General Subjects 1865(1):129759. doi: 10.1016/j.bbagen.2020.129759.

6. Qiao, Gan, Huanli Xu, Cong Li, Xiao Li, Ammad Ahmad Farooqi, Yuming Zhao, Xiaohui Liu, Ming Liu, Dimitrios Stagos, and Xiukun Lin. 2018. “Granulin A Synergizes with Cisplatin to Inhibit the Growth of Human Hepatocellular Carcinoma.” International Journal of Molecular Sciences 19(10). doi: 10.3390/ijms19103060.

7. Sambrook, Joseph, David William Russell, and J. Sambrook. 2006. The Condensed Protocols: From Molecular Cloning: A Laboratory Manual. Cold Spring Harbor Laboratory Press Cold Spring Harbor, NY.

8. Su, Shuonan, Huanli Xu, Xiaoliang Chen, Gan Qiao, Ammad A. Farooqi, Ye Tian, Ru Yuan, Xiaohui Liu, Cong Li, Xiao Li, Ning Wu, and Xiukun Lin. 2018. “CS5931, A Novel Marine Polypeptide, Inhibits Migration and Invasion of Cancer Cells Via Interacting with Enolase 1.” Recent Patents on Anti-Cancer Drug Discovery 13(3):360–67. doi: 10.2174/1574892813666180628170240.

9. Tao, Hongyu, Huanli Xu, Ling Zuo, Cong Li, Gan Qiao, Mingyue Guo, Lanhong Zheng, Maja Leitgeb, and Xiukun Lin. 2020. “Exosomes-Coated Bcl-2 SiRNA Inhibits the Growth of Digestive System Tumors Both in Vitro and in Vivo.” International Journal of Biological Macromolecules 161:470–80. doi: 10.1016/j.ijbiomac.2020.06.052.

10. Tao, Hongyu, Ling Zuo, Huanli Xu, Cong Li, Gan Qiao, Mingyue Guo, and Xiukun Lin. 2020. “Alkaloids as Anticancer Agents: A Review of Chinese Patents in Recent 5 Years.” Recent Patents on Anti-Cancer Drug Discovery. doi: 10.2174/1574892815666200131120618.

11. Tian, Ye, Huanli Xu, Ammad Ahmad Farooq, Baozeng Nie, Xiaoliang Chen, Shuonan Su, Ru Yuan, Gan Qiao, Cong Li, Xiao Li, Xiaohui Liu, and Xiukun Lin. 2018. “Maslinic Acid Induces Autophagy by Down-Regulating HSPA8 in Pancreatic Cancer Cells.” Phytotherapy Research 32(7):1320–31. doi: 10.1002/ptr.6064.

12. Wu, An-Guo, Xiao-Gang Zhou, Gan Qiao, Lu Yu, Yong Tang, Lu Yan, Wen-Qiao Qiu, Rong Pan, Chong-Lin Yu, Betty Yuen-Kwan Law, Da-Lian Qin, and Jian-Ming Wu. 2020. “Targeting Microglial Autophagic Degradation in NLRP3 Inflammasome-Mediated Neurodegenerative Diseases.” Ageing Research Reviews 65:101202. doi: 10.1016/j.arr.2020.101202.

13. Xu, Huanli, Ru Yuan, Xiaohui Liu, Xiao Li, Gan Qiao, Cong Li, Aharon Gedanken, and Xiukun Lin. 2019. “Zn-Doped CuO Nanocomposites Inhibit Tumor Growth by NF-ΚB Pathway Cross-Linked Autophagy and Apoptosis.” Nanomedicine (London, England) 14(2):131–49. doi: 10.2217/nnm-2018-0366.

14. Zuo, Ling, Hongyu Tao, Huanli Xu, Cong Li, Gan Qiao, Mingyue Guo, Shousong Cao, Minghua Liu, and Xiukun Lin. 2020. “Exosomes-Coated MiR-34a Displays Potent Antitumor Activity in Pancreatic Cancer Both in Vitro and in Vivo.” Drug Design, Development and Therapy 14:3495–3507. doi: 10.2147/DDDT.S265423.

主要主持或参与科研项目：

1. 重塑PGRN/granulins介导的溶酶体功能改善前额颞叶痴呆病变的分子机制研究，厅市共建中枢神经系统药物四川省重点实验室，2020/10-2022/09，5万-主持；

2. 基于山楂酸与HSF-1相互作用下调HSPA8，研究其与吉西他滨协同抑制胰腺癌生长的分子机制，西南医科大学校级项目，2021/01-2022/12，1万元-主持

3. 抗肿瘤新药纳米RNA及纳米多肽的研制与开发，四川省科技厅，国际合作2017HH0104，20万-参与；

4. Granulin A与ENO1相互作用及其抑制肿瘤生长和转移的分子机制研究，国家自然科学基金，面上项目，81773776，25万-参与；

5. 中药“酸酚胶囊”抗胰腺癌的临床前研究，四川省科技厅，重点研发项目，2019YFS0116，2019/01-2021/12，20万-参与；

通讯信息

单位：西南医科大学药学院药理学教研室

通讯地址：四川省泸州市江阳区忠山路三段319号-西南医科大学

E-mail: dqz377977905@swmu.edu.cn