沈晶(1985-),女,研究员,硕士研究生导师,香港中文大学博士毕业,中国药理学会会员,中国研究型医院学会病毒肿瘤学专业委员会委员,四川省肿瘤药理专委会委员,Current Pharmaceutical Design杂志客座编辑,Current Medicinal Chemistry, Growth Factors,Phytomedicine, Journal of Ethnopharmacology等杂志特邀审稿人。近年来先后在Cancer Research、Autophagy 、Theranostics、OncoImmunology 等重要国际期刊发表SCI论文近70篇。
研究方向:
非编码RNA及表观调控在癌症中的功能及机制研究
学习及工作经历:
2018/11-至今, 西南医科大学,药学院,研究员
2016/04-2018/10, 西南医科大学,药学院,副研究员
2013/09-2015/12, 香港中文大学,生物医学学院,博士后
2010/08-2013/08, 香港中文大学,生物医学学院,博士
2007/08-2010/07, 中国药科大学,生命科学与技术学院,硕士
2003/09-2007/07, 中国药科大学,生命科学与技术学院,学士
代表性SCI论文:
1. Zhao Q, Zhao Y, Hu W, Zhang Y, Wu X, Lu J, Li M, Li W, Wu W, Wang J, Du F, Ji H, Yang X, Xu Z, Wan L, Wen Q, Li X, Cho CH, Zou C, Shen J*, Xiao Z. m6A RNA modification modulates PI3K/Akt/mTOR signal pathway in Gastrointestinal Cancer. Theranostics. 2020;10(21):9528-9543.
2. Xu Wu^, Jing Shen^, Zhangang Xiao, Jing Li, Yueshui Zhao, Qijie Zhao, Chi Hin Cho*, Mingxing Li*. An overview of the multifaceted roles of miRNAs in gastric cancer: Spotlight on novel biomarkers and therapeutic targets. Biochemical Pharmacology, 2019(163):425-439.
3.Xu Z, Xia Y, Xiao Z, Jia Y, Zhu Y, Jin Y, Zhao Q, Wan L, Yi T, Yu Y, Zhu Y, Zhang F, Shen J*. Comprehensive profiling of JMJD3 in gastric cancer and its influence on patient survival. Scientific Reports. 2019, 9(1):868.
4. Shen J, Xiao Z, Zhao Q, Li M, Wu X, Zhang L, Cho CH. (2018) Anti-cancer Therapy with TNFα and IFNγ: a comprehensive review, Cell Proliferation, 51(4):e12441.
5. Lin L, Zhao Y, Xiao Z, Li M, Wu X, Li W, Li X, Zhao Q, Wu Y, Zhang H, Yin J, Zhang L, Cho CH, Shen J*. (2018) Protective role of γδ T cells in different pathogen infections and its potential clinical application. Journal of Immunology Research. 10;2018:5081634.
4.Xu ZY^, Shen J^, Wang MH, Yi T, Yu YY, Zhu YX, Chen B, Chen JP, Li LF, Li MX, Zuo J, Jiang H, Zhou DX, Luan J, Xiao Z. Comprehensive molecular profiling of the B7 family of immune-regulatory ligands in breast cancer. OncoImmunology. 2016 Jul 11;5(8):e1207841.
5.Shen J, Li ZJ, Li LF, Lu L, Xiao Z, Wu WK, Zhang L, Li MX, Hu W, Chan KM, Cho CH. Vascular-targeted TNFα and IFNγ inhibits orthotopic colorectal tumor growth. J Transl Med. 2016 Jun 24;14(1):187.
6.Shen J, Xiao Z, Wu WK, Wang MH, To KF, Chen Y, Yang W, Li SM, Shin VY, Tong JH, Kang W, Zhang L, Li M, Wang L, Lu L, Chan RLY, Wong SH, Yu J, Chan MTV, Chan FKL, Sung JJY, Cheng ASL, Cho CH. (2015). Epigenetic silencing of miR-490-3p reactivates the chromatin remodeler SMARCD1 to promote Helicobacter pylori-induced gastric carcinogenesis. Cancer Res. 15;75(4):754-65.
7.Shen J, Li WX, Xiao ZG, Zhang L, Li MX, Li LF, Hu W, Lu L, Boudreau F, Cho CH. The Co-regulatory Role of 5-Lipoxygenase and Cyclooxygenase-2 in the Carcinogenesis and their Promotion by Cigarette Smoking in Colons. Curr Med Chem. 2016;23(11):1131-8.
主持科研项目:
1. 四川省科技厅项目,2021YJ0201,非编码小RNA-34a(microRNA-34a)小分子调控剂的抗肝癌效应及作用机制研究,2021.1-2024.12,15万人民币
2. 2020-2022年度西南医科大学青年科技特别支持计划,2020.1-2022.12,20万人民币
3. 国家自然科学基金-青年基金,81602166,维生素D和抗菌肽在预防胃癌、逆转胃癌耐药中的作用及机理,2017.1-2019.12,19万人民币
4. 泸州市-西南医大联合项目-面上项目,2017LZXNYD-J09,新一代循环癌细胞(CTCs)检测技术在胃肠癌个性化诊疗中的应用,2017.1-2019.12,10万人民币
5. 四川好医生攀西药业有限责任公司,横向课题,康复新液治疗幽门螺旋杆菌感染小鼠的研究,2018.1-2019.12,20万人民币
硕士研究生招生方向:
非编码RNA和表观遗传调控在癌症中的作用