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药物化学教研室

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付强 副教授 (硕士生导师)

发布日期:2021-05-24    作者:     来源:     点击:

付强,博士,副教授,硕士生导师,药学院药物化学教研室从事教学和科研,泸州市企业科技特派员。研究方向:新药创制(神经精神疾病药物、可见光促进的化学反应及反应机制和绿色制药工艺。主持国家自然科学基金青年项目1项、四川省科技厅项目1项,泸州市-西南医大联合项目2项、校级课题3项;已发表SCI论文30余篇,其中第一作者或通讯作者SCI论文21篇,包括Nature Communications, ACS Catalysis, ACS Applied Materials & Interfaces, Organic Chemistry Frontiers, Chemical Communications, Advanced Synthesis & Catalysis, Chinese Chemical Letters, Chinese Journal of Chemistry期刊

招生方向:热忱欢迎有志于从事药物化学、光化学研究的学生加入我的团队,共同探索未知,为药物研发事业贡献力量。

100701药物化学(学术型硕士);

105500药学硕士(药物合成与工艺优化,专业型硕士)

邮箱: fuqiang@swmu.edu.cn; fuqiang0720@126.com

教育和工作经历:

2008.09―2012.07,青岛科技大学,制药工程,学士学位,导师:康从民教授

2012.09―2017.07,中国科学院成都生物研究所,药物化学,博士,导师:姬建新研究员

2017.11―2019.07,四川大学,访问教师,导师:余达刚教授

2017.07―2020.11,西南医科大学,药学院,药物化学教研室,讲师

2020.12―至今,西南医科大学,药学院,药物化学教研室,副教授

研究方向:

1、 新药创制(神经精神疾病药物的设计与合成及活性评价

2、 可见光促进的化学反应及反应机制

3、 绿色制药工艺

发表论文:

第一(通讯)作者论文:

1. Yihao Zhang, Peng Zhang, Hang Zhao, Xing Wang, Xia Zhou, Yimou Gong, Lin Wang, Siping Wei, Zhijie Zhang, Qiang Fu*, Solvent-Controlled 4CzBnBN-Catalyzed Intramolecular Photocyclization and Dehydrogenative Photocyclization of Indolecarboxamides for the Switchable Synthesis of Indoloquinolones and Dihydroindoloquinolones, Org. Chem. Front., 2025, 12, 3976.

2. Yingying Jiang, Hang Zhao, Lunjie Chen, Siping Wei, Jun Wang, Lin Wang, Qiang Fu*, Rapid Synthesis of Pomalidomide-Conjugates in Minutes Via Temperature Elevation and Delayed Feeding, Chem. Commun., 2025, 61, 5814.

3. Li Yang, Yi Pan, Peng Zhang, Liping Shi, Sheng Huang, Yijing Shu, Zhijie Zhang, Yimou Gong, Li Wang, Kai-Chung Lau,* Qiang Fu*. Energy Transfer-Mediated, Triplet Excited State Proton Transfer-Enabled Dearomatization of Indole Derivatives with Amide Functionalities. Chin. J. Chem., 2025, 43, 1129-1134.

4. Daling Li; Jun Wei; Lixu Ren; Lingmin Zhou; Liya Huang; Ying Yu; Siping Wei; Na Hao; Jun Wang; Lin Yang; Xianchao Pan; Qiang Fu*; Ji Lu*. Dual Photoexcited Palladium and Photoredox-Catalyzed Remote C(sp3)–H Acylation of Hydroxyamides. Org. Lett. 2025, 27, 4479-4484.

5. Chuan Feng; Xiong Cheng; Zhihui Xiang; Jiwei Peng; Yimou Gong; Siping Wei*; Qiang Fu*; Zhijie Zhang*. Synthesis of Dihydroisoquinolone-Fused Cyclobutanes via Tandem Palladium-Mediated Olefin Migration and Photosensitized [2 + 2] Cycloaddition. Org. Lett. 2025, 27, 12237-12242.

6. Chuan Feng; Yilei Liu; Zhihui Xiang; Xiong Cheng; Siping Wei; Xinran Liu; Qinmin Deng; Qiang Fu*; Zhijie Zhang*. An Organic EnT Photocatalyst 4CzMeBN and the Application in the Synthesis of cis-Fused Azetidines. Chem. Eur. J. 2025, 31, e202403881.

7. Yishu He, Yihao Zhang, Hang Zhao, Xing Wang, Gaofeng He, Rong Huang, Siping Wei, Zhijie Zhang*, Qiang Fu*. Photocatalytic Dehydrogenative 6π-Photocyclisation of Indole Derivatives via Successive Energy Transfer. Adv. Synth. Catal., 2024, 366, 508-514.

8. Lan Xia, Long Yuan, Kai Zhou, Jing Zeng, Kailian Zhang, Guocan Zheng, Qiang Fu*, Zhining Xia*, Qifeng Fu*. Mixed-Solvent-Mediated Strategy for Enhancing Light Absorption of Polydopamine and Adhesion Persistence of Dopamine Solutions. ACS Applied Materials & Interfaces 2023, 15(18), 22493–22505.

9. Ting Zou#, Yishu He#, Rui Liu, Yihao Zhang, Siping Wei*, Ji Lu, Jun Wang, Lin Wang, Qiang Fu*, Dong Yi*. Photoredox-neutral ring-opening pyridylation of cyclic oximes via phosphoranyl radical-mediated N-O/C-C bond cleavages and sequential radical-radical coupling. Chin. Chem. Lett., 2023, 34, 107822.

10. Kunrong Shen; Chuan Feng; Yilei Liu; Dong Yi; Peng Lin; Huifang Li; Yimou Gong; Siping Wei*; Qiang Fu*; Zhijie Zhang*. Visible light-enabled synthesis of phosphorylated indolizine and pyridoindole derivatives via HAT-mediated radical cascade cyclization. Org. Biomol. Chem. 2023, 21, 9341-9345.

11. Hao Li, Yishu He, Di Zhang, Li Yang, Jiarui Zhang, Rui-ling Long, Ji Lu, Jun Wei, Lin Yang, Siping Wei, Dong Yi*, Zhijie Zhang*, Qiang Fu*. Hydrogen Bond Serving as a Protecting Group to Enable the Photocatalytic [2+2] Cycloaddition of Redox-Active Aliphatic-Amine-Containing Indole Derivatives. Chem. Commun. 2022, 58, 3194-3197.

12. Luo Junfei*, Fu Qiang*. Aldehyde-Directed C(sp2)H Functionalization under Transition-Metal Catalysis. Adv. Synth. Catal., 2021, 363, 3868.

13. Zhijie Zhang,# Dong Yi,# Min Zhang, Jun Wei, Ji Lu, Lin Yang, Jun Wang, Na Hao, Xianchao Pan, Shiqi Zhang,* Siping Wei,* Qiang Fu*. Photocatalytic Intramolecular [2+2] Cycloaddition of Indole Derivatives via Energy Transfer: A Method for Late-Stage Skeletal Transformation. ACS Catal., 2020, 10, 10149.

14. Qiang Fu, Zhi-Yu Bo, Jian-Heng Ye, Tao Ju, He Huang, Li-Li Liao, and Da-Gang Yu*. Transition metal-free phosphonocarboxylation of alkenes with carbon dioxide via visible-light photoredox catalysis. Nat. Commun., 2019, 10, 3592.

15. Qiang Fu, Dong Yi, Zhi-jie Zhang, Wu Liang Suyuan Chen, Lu Yang, Qiang Zhang*, Jian-Xin Ji, Wei Wei*. Copper-catalyzed aerobic oxidative coupling of ketones with P(O)-H compounds leading to β-ketophosphine oxides. Org. Chem. Front., 2017, 4, 1385.

16. Dong Yi,*,# Linying He,# Zhongyu Qi, Zhijie Zhang, Mengshun Li, Ji Lu, Jun Wei, Xi Du, Qiang Fu*, Siping Wei*. Copper-catalyzed aerobic oxidative cleavage of unstrained carbon-carbon bonds of 1,1-disubstituted alkenes with sulfonyl hydrazides. Chin. J. Chem., 2021, 39, 859.

17. Yue-Ming Jiang,# Jie Liu,# Qiang Fu,* Yu-Ming Yu,* Da-Gang Yu*. Visible-Light-Driven Phosphonoalkylation of Alkenes. Synlett, 2021, 32, 378.

18. Liu Jie#, Xiao Han-Zhi#, Fu Qiang*, Yu Da-Gang*. Advances in Radical Phosphorylation from 2016 to 2021. Chemical Synthesis 2021, 1, 9.

19. Qi Zhongyu#, Zhang Zhijie#, Yang Li, Zhang Di, Lu Ji, Wei Jun, Wei Siping, Qiang Fu*, Du Xi*, Dong Yi*. Nitrogen-Radical-Triggered Trifunctionalizing ipso-Spirocyclization of Unactivated Alkenes with Vinyl Azides: A Modular Access to Spiroaminal Frameworks. Adv. Synth. Catal. 2021, 363, 3762.

20. 董凯凯,黄强,易东,姬建新,付强*,碘催化色酮与吡啶乙酸乙酯[3+2]环化合成结构新颖的中氮茚类化合物. 华西药学杂志,2020, 35, 016.

21. 陈长友,易东,韦思平,付强*,铜催化的芳基乙烯与胺基磺酰氯偶联合成反式烯基磺酰胺. 华西药学杂志,2019, 34, 010.

共同作者论文:

1. Wei Wang; Bin Chen; Ting Li; Zhengchu Chen; Lei Yuan; Qiang Fu; Siping Wei; Xiao-Feng Wu; Dong Yi. Photoredox-catalyzed four-atom skeletal editing of 1,3-diketones with alkenes and aldehydes. Chin. J. Catal. 2026, 82, 212-224.

2. Tao Ju; Zhi-Cheng Wei; Min Ge; Ying-Ying Ma; Sheng Huang; Jing Sun; Qiang Fu; Ying Han; Chao-Guo Yan. Photocatalytic Selective Synthesis of Hemiketals from Alkenes, α-Halo Acylarenes, and Water via N-Methylindole Catalysis. Org. Lett. 2026, 28, 2711-2717.

3. Ran Yang, Dong Yi, Kunrong Shen, Qiang Fu, Jun Wei, Ji Lu, Lin Yang, Li Wang, Siping Wei, Zhijie Zhang. Indole and Pyrrole Derivatives as Pre-Photocatalysts and Substrates in the Sulfonyl Radical-Triggered Relay Cyclization Leading to Sulfonylated Heterocycles. Org. Lett., 2022; 24, 2014.

4. Yue Tong, Na Hao, Long Zhang, Jun Wei, Zhijie Zhang, Qiang Fu, Dong Yi, Yao Mou, Jun Wang, Xianchao Pan, Lin Yang, Siping Wei, Lei Zhong, Ji Lu. Photocatalytic Redox-Neutral Arylation of Cyclopropanols with Cyanoarenes via Radical-Mediated C–C and C–CN Bond Cleavage. Organic Chemistry Frontiers 2022, 9, 2129.

5. Ju Tao, Zhou Yu-Qin, Cao Ke-Gong, Fu Qiang, Ye Jian-Heng, Sun Guo-Quan, Liu Xiao-Feng, Chen Li, Liao Li-Li, Yu Da-Gang. Dicarboxylation of Alkenes, Allenes and (Hetero)Arenes with CO2 via Visible-Light Photoredox Catalysis. Nature Catalysis 2021, 4, 304.

6. Weidong Chen, Hao Tang, Weilin Wang, Qiang Fu, Junfei Luo*. Catalytic Aerobic Dehydrogenatin of N-Heterocycles by N-Hydoxyphthalimide. Adv. Synth. Catal. 2020, 362, 3905-3911.

7. Lei Song, Dong-Min Fu, Liang Chen, Yuan-Xu Jiang, Jian-Heng Ye, Lei Zhu, Yu Lan*, Qiang Fu, Da-Gang Yu*. Visible-Light Photoredox-Catalyzed Remote Difunctionalizing Carboxylation of Unactivated Alkenes with CO2. Angew. Chem. Int. Ed., 2020, 59, 21121.

8. Tao Ju, Qiang Fu, Jian-Heng Ye, Zhen Zhang, Li-Li Liao, Si-Shun Yan, Xing-Yang Tian, Shu-Ping Luo, Jing Li, Da-Gang Yu*. Selective and Catalytic Hydrocarboxylation of Enamides and Imines with CO2 to Generate Quaternary α-Amino Acids. Angew. Chem. Int. Ed., 2018, 57 (42), 13897.

9. Si-Shun Yan, Qiang Fu, Li-Li Liao, Guo-Quan Sun, Jian-Heng Ye, Li Gong, Yin-Zi Bo-Xue, Da-Gang Yu*. Transition metal-catalyzed carboxylation of unsaturated substrates with CO2. Coordin. Chem. Rev., 2018, 374, 439.

10. Dong Yi, Qiang Fu, Su-Yuan Chen, Ming Gao, Lu Yang, Zhi-Jie Zhang, Wu Liang, Qiang Zhang*, Jian-Xin Ji, Wei Wei*. Copper-catalyzed direct hydroxyphosphorylation of electron-deficient alkenes with H-phosphine oxides and dioxygen. Tetrahedron Lett., 2017, 58 (21), 2058-2061.

11. 王华斌,付强,张智杰,高明, 姬建新,易东. 盐酸促进、铜/铁共催化2-取代丙烯酸酯与膦氧类化合物的脱酯氧膦化反应. 有机化学,201838, 1977.

12. Zhi-Jie Zhang, Dong Yi, Qiang Fu, Wu Liang, Su-Yuan Chen, Lu Yang, Feng-Tian Du*, Jian-Xin Ji, and Wei Wei*. Copper catalyzed one-pot synthesis of β-ketophosphine oxides from ketones and H-phosphine oxides. Tetrahedron Lett., 2017, 58(25), 2417-2420.

13. Wu Liang, Zhi-Jie Zhang, Dong Yi, Qiang Fu, Su-Yuan Chen, Lu Yang, Feng-Tian Du*, Jian-Xin Ji, Wei Wei*. Copper-catalyzed direct oxyphosphorylation of enamides with P(O)-H compounds and dioxygen. Chin. J. Chem., 2017, 35(9): 1378.

14. Su-Yuan Chen, Lu Yang, Dong Yi, Qiang Fu, Zhi-Jie Zhang, Wu Liang, Wei Wei*, Jian-Xin Ji, and Qiang Zhang*. Transition-metal-free PhI(OAc)2-catalyzed highly selective hydroboration of terminal alkynes under air. RSC Adv., 2017, 7, 26070.

15. 杨路,陈粟源,易东,付强,梁伍,张智杰,杜锋田,姬建新,曾庆乐*. Dess-Martin试剂促进吲哚硫醚合成反应的研究. 华西药学杂志, 2018, 33, 008

16. Pan Xiang,# Linying He,# Hao Li, Zhongyu Qi, Min Zhang, Qiang Fu, Jun Wei, Xi Du, Dong Yi*, Siping Wei*. Organo-Photoredox Catalyzed Defluoroacetalation of α-Trifluoromethyl Alkenes for Synthesis of Masked γ,γ-Difluoroallylic Aldehydes. Tetrahedron Lett. 2020, 61, 152369.

发明专利:

1、 付强,周霞,舒奕静,吴安国,韦思平;一种非经典铁死亡抑制剂及其制备方法和用途,申请号:2026101766580

2、 付强,张益豪,张朋,张智杰,韦思平;一种杂芳基稠合喹啉酮类化合物的制备方法,专利号:ZL 2024 1 1778011.2

3、 付强,何奕树,付强,何奕树,张益豪,赵航,王星,周娇,易东,张智杰,卢戢,魏军,王俊,韦思平;一种(杂)芳基稠和咔唑类化合物的制备方法及其应用,专利号:ZL 2023 1 0059779.3

4、 付强,李浩,杨丽,张智杰,易东,韦思平;一种环丁烷稠合的多环/桥环吲哚啉类化合物及其制备方法,公开号:CN 114014861A

5、 付强,杨丽,何奕树,周娇,张益豪,张智杰,易东,魏军,卢戢,郝娜,杨琳,韦思平;一种螺环二氢吲哚类化合物及其制备方法,公开号:CN 115490692A

6、 余达刚,李静,付强,伯知豫,叶剑衡,鞠涛,黄河,廖黎丽;一种含膦羧酸化合物及其制备方法,授权公告号:CN 110256492B

7、 易东,韦思平,张智杰,何林颖,戚仲钰,付强,卢戢,魏军;β-羰基砜类化合物的制备方法,公开号:CN 111978216A

8、 易东,张敏,张智杰,韦思平,付强,卢戢,魏军,戚仲钰,邹婷;一种偕二氟烯烃-吡咯啉类化合物及其制备方法与应用,公开号:CN 113149882A