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药物化学教研室

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付强 副教授 (硕士生导师)

发布日期:2021-05-24    作者:     来源:     点击:

付强,博士,副教授,硕士生导师,药学院药物化学教研室从事教学和科研,泸州市企业科技特派员。研究方向:新药创制(神经精神疾病药物、病媒防控药物、可见光促进的化学反应及反应机制和绿色制药工艺。主持国家自然科学基金青年项目1项、四川省科技厅项目1项,泸州市-西南医大联合项目2项、校级课题3项;已发表SCI论文30余篇,其中第一作者或通讯作者SCI论文15篇,包括Nature Communications, ACS Catalysis, ACS Applied Materials & Interfaces, Organic Chemistry Frontiers, Chemical Communications, Advanced Synthesis & Catalysis, Chinese Chemical Letters, Chinese Journal of Chemistry期刊

招生方向:热忱欢迎有志于从事药物化学、光化学研究的学生加入我的团队,共同探索未知,为药物研发事业贡献力量。

100701药物化学(学术型硕士);

105500药学硕士(药物合成与工艺优化,专业型硕士)

邮箱: fuqiang@swmu.edu.cn; fuqiang0720@126.com

教育和工作经历:

2008.09―2012.07,青岛科技大学,制药工程,学士学位,导师:康从民教授

2012.09―2017.07,中国科学院成都生物研究所,药物化学,博士,导师:姬建新研究员

2017.11―2019.07,四川大学,访问教师,导师:余达刚教授

2017.07―2020.11,西南医科大学,药学院,药物化学教研室,讲师

2020.12―至今,西南医科大学,药学院,药物化学教研室,副教授

研究方向:

1、 新药创制(神经精神疾病药物;病媒防控药物

2、 可见光促进的化学反应及反应机制

3、 绿色制药工艺

主持项目:

1、国家自然科学基金青年基金项目1项;

2、四川省科技厅项目1项;

3、泸州市西南医大联合项目2项;

4、西南医科大学自科重点项目1项;青年项目1项;西南医科大学2022-2024年特别支持计划。

发表论文:

第一(通讯)作者论文:

1. Yihao Zhang, Peng Zhang, Hang Zhao, Xing Wang, Xia Zhou, Yimou Gong, Lin Wang, Siping Wei, Zhijie Zhang, Qiang Fu*, Solvent-Controlled 4CzBnBN-Catalyzed Intramolecular Photocyclization and Dehydrogenative Photocyclization of Indolecarboxamides for the Switchable Synthesis of Indoloquinolones and Dihydroindoloquinolones, Org. Chem. Front., 2025, 10.1039/D5QO00185D.

2. Yingying Jiang, Hang Zhao, Lunjie Chen, Siping Wei, Jun Wang, Lin Wang, Qiang Fu*, Rapid Synthesis of Pomalidomide-Conjugates in Minutes Via Temperature Elevation and Delayed Feeding, Chem. Commun., 2025, 10.1039/D5CC00611B.

3. Li Yang, Yi Pan, Peng Zhang, Liping Shi, Sheng Huang, Yijing Shu, Zhijie Zhang, Yimou Gong, Li Wang, Kai-Chung Lau,* Qiang Fu*. Energy Transfer-Mediated, Triplet Excited State Proton Transfer-Enabled Dearomatization of Indole Derivatives with Amide Functionalities. Chin. J. Chem., 2025, 43, 1129-1134.

4. Yishu He, Yihao Zhang, Hang Zhao, Xing Wang, Gaofeng He, Rong Huang, Siping Wei, Zhijie Zhang*, Qiang Fu*. Photocatalytic Dehydrogenative 6π-Photocyclisation of Indole Derivatives via Successive Energy Transfer. Adv. Synth. Catal., 2024, 366, 508-514.

5. Lan Xia, Long Yuan, Kai Zhou, Jing Zeng, Kailian Zhang, Guocan Zheng, Qiang Fu*, Zhining Xia*, Qifeng Fu*. Mixed-Solvent-Mediated Strategy for Enhancing Light Absorption of Polydopamine and Adhesion Persistence of Dopamine Solutions. ACS Applied Materials & Interfaces 2023, 15(18), 22493–22505.

6. Ting Zou#, Yishu He#, Rui Liu, Yihao Zhang, Siping Wei*, Ji Lu, Jun Wang, Lin Wang, Qiang Fu*, Dong Yi*. Photoredox-neutral ring-opening pyridylation of cyclic oximes via phosphoranyl radical-mediated N-O/C-C bond cleavages and sequential radical-radical coupling. Chin. Chem. Lett., 2023, 34, 107822.

7. Hao Li, Yishu He, Di Zhang, Li Yang, Jiarui Zhang, Rui-ling Long, Ji Lu, Jun Wei, Lin Yang, Siping Wei, Dong Yi*, Zhijie Zhang*, Qiang Fu*. Hydrogen Bond Serving as a Protecting Group to Enable the Photocatalytic [2+2] Cycloaddition of Redox-Active Aliphatic-Amine-Containing Indole Derivatives. Chem. Commun. 2022, 58, 3194-3197.

8. Luo Junfei*, Fu Qiang*. Aldehyde-Directed C(sp2)H Functionalization under Transition-Metal Catalysis. Adv. Synth. Catal., 2021, 363, 3868.

9. Zhijie Zhang,# Dong Yi,# Min Zhang, Jun Wei, Ji Lu, Lin Yang, Jun Wang, Na Hao, Xianchao Pan, Shiqi Zhang,* Siping Wei,* Qiang Fu*. Photocatalytic Intramolecular [2+2] Cycloaddition of Indole Derivatives via Energy Transfer: A Method for Late-Stage Skeletal Transformation. ACS Catal., 2020, 10, 10149.

10. Qiang Fu, Zhi-Yu Bo, Jian-Heng Ye, Tao Ju, He Huang, Li-Li Liao, and Da-Gang Yu*. Transition metal-free phosphonocarboxylation of alkenes with carbon dioxide via visible-light photoredox catalysis. Nat. Commun., 2019, 10, 3592.

11. Qiang Fu, Dong Yi, Zhi-jie Zhang, Wu Liang Suyuan Chen, Lu Yang, Qiang Zhang*, Jian-Xin Ji, Wei Wei*. Copper-catalyzed aerobic oxidative coupling of ketones with P(O)-H compounds leading to β-ketophosphine oxides. Org. Chem. Front., 2017, 4, 1385.

12. Dong Yi,*,# Linying He,# Zhongyu Qi, Zhijie Zhang, Mengshun Li, Ji Lu, Jun Wei, Xi Du, Qiang Fu*, Siping Wei*. Copper-catalyzed aerobic oxidative cleavage of unstrained carbon-carbon bonds of 1,1-disubstituted alkenes with sulfonyl hydrazides. Chin. J. Chem., 2021, 39, 859.

13. Yue-Ming Jiang,# Jie Liu,# Qiang Fu,* Yu-Ming Yu,* Da-Gang Yu*. Visible-Light-Driven Phosphonoalkylation of Alkenes. Synlett, 2021, 32, 378.

14. Liu Jie#, Xiao Han-Zhi#, Fu Qiang*, Yu Da-Gang*. Advances in Radical Phosphorylation from 2016 to 2021. Chemical Synthesis 2021, 1, 9.

15. Qi Zhongyu#, Zhang Zhijie#, Yang Li, Zhang Di, Lu Ji, Wei Jun, Wei Siping, Qiang Fu*, Du Xi*, Dong Yi*. Nitrogen-Radical-Triggered Trifunctionalizing ipso-Spirocyclization of Unactivated Alkenes with Vinyl Azides: A Modular Access to Spiroaminal Frameworks. Adv. Synth. Catal. 2021, 363, 3762.

16. 董凯凯,黄强,易东,姬建新,付强*,碘催化色酮与吡啶乙酸乙酯[3+2]环化合成结构新颖的中氮茚类化合物. 华西药学杂志,2020, 35, 016.

17. 陈长友,易东,韦思平,付强*,铜催化的芳基乙烯与胺基磺酰氯偶联合成反式烯基磺酰胺. 华西药学杂志,2019, 34, 010.

共同作者论文:

1. Ran Yang, Dong Yi, Kunrong Shen, Qiang Fu, Jun Wei, Ji Lu, Lin Yang, Li Wang, Siping Wei, Zhijie Zhang. Indole and Pyrrole Derivatives as Pre-Photocatalysts and Substrates in the Sulfonyl Radical-Triggered Relay Cyclization Leading to Sulfonylated Heterocycles. Org. Lett., 2022; 24, 2014.

2. Yue Tong, Na Hao, Long Zhang, Jun Wei, Zhijie Zhang, Qiang Fu, Dong Yi, Yao Mou, Jun Wang, Xianchao Pan, Lin Yang, Siping Wei, Lei Zhong, Ji Lu. Photocatalytic Redox-Neutral Arylation of Cyclopropanols with Cyanoarenes via Radical-Mediated C–C and C–CN Bond Cleavage. Organic Chemistry Frontiers 2022, 9, 2129.

3. Ju Tao, Zhou Yu-Qin, Cao Ke-Gong, Fu Qiang, Ye Jian-Heng, Sun Guo-Quan, Liu Xiao-Feng, Chen Li, Liao Li-Li, Yu Da-Gang. Dicarboxylation of Alkenes, Allenes and (Hetero)Arenes with CO2 via Visible-Light Photoredox Catalysis. Nature Catalysis 2021, 4, 304.

4. Weidong Chen, Hao Tang, Weilin Wang, Qiang Fu, Junfei Luo*. Catalytic Aerobic Dehydrogenatin of N-Heterocycles by N-Hydoxyphthalimide. Adv. Synth. Catal. 2020, 362, 3905-3911.

5. Lei Song, Dong-Min Fu, Liang Chen, Yuan-Xu Jiang, Jian-Heng Ye, Lei Zhu, Yu Lan*, Qiang Fu, Da-Gang Yu*. Visible-Light Photoredox-Catalyzed Remote Difunctionalizing Carboxylation of Unactivated Alkenes with CO2. Angew. Chem. Int. Ed., 2020, 59, 21121.

6. Tao Ju, Qiang Fu, Jian-Heng Ye, Zhen Zhang, Li-Li Liao, Si-Shun Yan, Xing-Yang Tian, Shu-Ping Luo, Jing Li, Da-Gang Yu*. Selective and Catalytic Hydrocarboxylation of Enamides and Imines with CO2 to Generate Quaternary α-Amino Acids. Angew. Chem. Int. Ed., 2018, 57 (42), 13897.

7. Si-Shun Yan, Qiang Fu, Li-Li Liao, Guo-Quan Sun, Jian-Heng Ye, Li Gong, Yin-Zi Bo-Xue, Da-Gang Yu*. Transition metal-catalyzed carboxylation of unsaturated substrates with CO2. Coordin. Chem. Rev., 2018, 374, 439.

8. Dong Yi, Qiang Fu, Su-Yuan Chen, Ming Gao, Lu Yang, Zhi-Jie Zhang, Wu Liang, Qiang Zhang*, Jian-Xin Ji, Wei Wei*. Copper-catalyzed direct hydroxyphosphorylation of electron-deficient alkenes with H-phosphine oxides and dioxygen. Tetrahedron Lett., 2017, 58 (21), 2058-2061.

9. 王华斌,付强,张智杰,高明, 姬建新,易东. 盐酸促进、铜/铁共催化2-取代丙烯酸酯与膦氧类化合物的脱酯氧膦化反应. 有机化学,201838, 1977.

10. Zhi-Jie Zhang, Dong Yi, Qiang Fu, Wu Liang, Su-Yuan Chen, Lu Yang, Feng-Tian Du*, Jian-Xin Ji, and Wei Wei*. Copper catalyzed one-pot synthesis of β-ketophosphine oxides from ketones and H-phosphine oxides. Tetrahedron Lett., 2017, 58(25), 2417-2420.

11. Wu Liang, Zhi-Jie Zhang, Dong Yi, Qiang Fu, Su-Yuan Chen, Lu Yang, Feng-Tian Du*, Jian-Xin Ji, Wei Wei*. Copper-catalyzed direct oxyphosphorylation of enamides with P(O)-H compounds and dioxygen. Chin. J. Chem., 2017, 35(9): 1378.

12. Su-Yuan Chen, Lu Yang, Dong Yi, Qiang Fu, Zhi-Jie Zhang, Wu Liang, Wei Wei*, Jian-Xin Ji, and Qiang Zhang*. Transition-metal-free PhI(OAc)2-catalyzed highly selective hydroboration of terminal alkynes under air. RSC Adv., 2017, 7, 26070.

13. 杨路,陈粟源,易东,付强,梁伍,张智杰,杜锋田,姬建新,曾庆乐*. Dess-Martin试剂促进吲哚硫醚合成反应的研究. 华西药学杂志, 2018, 33, 008

14. Pan Xiang,# Linying He,# Hao Li, Zhongyu Qi, Min Zhang, Qiang Fu, Jun Wei, Xi Du, Dong Yi*, Siping Wei*. Organo-Photoredox Catalyzed Defluoroacetalation of α-Trifluoromethyl Alkenes for Synthesis of Masked γ,γ-Difluoroallylic Aldehydes. Tetrahedron Lett. 2020, 61, 152369.

发明专利:

1、 付强,何奕树,付强,何奕树,张益豪,赵航,王星,周娇,易东,张智杰,卢戢,魏军,王俊,韦思平;一种(杂)芳基稠和咔唑类化合物的制备方法及其应用,专利号:ZL 2023 1 0059779.3

2、 付强,李浩,杨丽,张智杰,易东,韦思平;一种环丁烷稠合的多环/桥环吲哚啉类化合物及其制备方法,公开号:CN 114014861A

3、 付强,杨丽,何奕树,周娇,张益豪,张智杰,易东,魏军,卢戢,郝娜,杨琳,韦思平;一种螺环二氢吲哚类化合物及其制备方法,公开号:CN 115490692A

4、 余达刚,李静,付强,伯知豫,叶剑衡,鞠涛,黄河,廖黎丽;一种含膦羧酸化合物及其制备方法,授权公告号:CN 110256492B

5、 易东,韦思平,张智杰,何林颖,戚仲钰,付强,卢戢,魏军;β-羰基砜类化合物的制备方法,公开号:CN 111978216A

6、 易东,张敏,张智杰,韦思平,付强,卢戢,魏军,戚仲钰,邹婷;一种偕二氟烯烃-吡咯啉类化合物及其制备方法与应用,公开号:CN 113149882A