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药物化学教研室

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简瑶 讲师

发布日期:2021-05-11    作者:简瑶     来源:     点击:

简瑶:女,籍贯四川泸州,中共党员,博士研究生学历,讲师。

研究方向:光功能过渡金属配合物的设计、合成及应用(抗肿瘤、抗菌治疗)。

教育经历:2014.09-2018.06,就读于西华大学化学专业,获得理学学士学位;2018.09-2023.06就读于中国科学院理化技术研究所有机化学专业,获得理学博士学位。

代表论文:

1.  Jian Y, Jin Z, Qi S, Da X, Wang Z, Wang X, Zhou Q, An alkynyl-dangling Ru(II) polypyridine complex for targeted antimicrobial photodynamic therapy [J].  Chemistry - A European Journal, 2022, 28: e202103359.

2. Jian Y, Peng Y, Zhou W, Xu Y, Li C, Wang X, Zhou Q, Ru(II) complexes with enaminone structures for rapid sterilization of Staphylococcus aureus and MRSA with little accumulation of drug resistance [J]. ChemMedChem, 2023: e202300065.

3. Sun W1, Jian Y1, Zhou M, Yao Y, Tian N, Li C, Chen J, Wang X, Zhou Q, Selective and efficient photoinactivation of intracellular Staphylococcus aureus and MRSA with little accumulation of drug resistance: application of a Ru(II) complex with photolabile ligands [J]. Journal of Medicinal Chemistry 2021, 64 (11): 7359-7370.

4. Jin Z, Qi S, Guo X, Jian Y, Hou Y, Li C, Wang X, Zhou Q, The modification of a pyrene group makes a Ru(II) complex versatile [J]. Chemical Communications, 2021, 57 (26): 3259-3262.

5. Qi S, Jin Z, Jian Y, Hou Y, Li C, Zhao Y, Wang X, Zhou Q, Photo-induced mitochondrial DNA damage and NADH depletion by -NO2 modified Ru(II) complexes [J]. Chemical Communications, 2021, 57 (34): 4162-4165.

6. Da X, Wang Z, Jian Y, Zhang C, Hou Y, Yao Y, Wang X, Zhou Q, A targeted and efficient CDT system with photocatalytic supplement of H2O2 and hydroxyl radical production at a neutral Ph [J]. Inorganic Chemistry Frontiers, 2022, 9 (11): 2544-2556.

7. Da X, Yu F H, Zhang C, Wang Z, Jian Y, Hou Y, Chen Y, Wang X, Zhou Q, A bioorthogonal assembly based on metallophilic interactions for selective imaging and PDT treatment of cancer cells [J]. Inorganic Chemistry Frontiers, 2022, 9: 2290-2297.

8. Wang Z, Gao C, Da X, Jian Y, Zhang C, Yao Y, Wang X, Zhou Q, Biocompatible hypocrellin A-Fe(III) nanoparticles exhibiting efficient photo-activated CDT in vitro and in vivo [J]. Dalton Transactions, 2022, 51 (8): 3225-3233.

9. Jin Z, Qi S, Guo X, Jian Y, Hou Y, Li C, Wang X, Zhou Q, Pyrene modification enables enhanced two-photon excited ligand dissociation of a Ru(II) complex containing monodentate ligands [J]. Inorganica Chimica Acta 2021, 524: 120435.

E-mail: jianyao@swmu.edu.cn

通讯地址:四川省泸州市龙马潭区香林路11号西南医科大学药学院药物化学教研室(弘润楼),邮编646000