周霞，女，1995年8月生，籍贯重庆南川，中共党员，药学博士研究生，西南医科大学药学院药物化学教研室讲师。

研究方向：小分子靶向药物的设计、合成及生物活性研究，新药早期成药性评价

教育经历： 2014.09-2018.06，就读于四川农业大学动物医学院药学专业，获得理学学士学位；2018.09-2023.06，就读于四川大学生物治疗国家重点实验室药学专业，获得理学博士学位

代表论文：

1. Zhou, X.^#; Tan, Y.^#; Gou, K.^#; Tao, L.; Luo, Y.; Zhou, Y.; Zuo, Z.; Sun, Q.^*; Luo, Y. ^*; Zhao, Y.^* Discovery of novel inhibitors of human phosphoglycerate dehydrogenase by activity-directed combinatorial chemical synthesis strategy. Bioorg Chem 2021, 115, 105159.

2. Tan, Y.^#; Zhou, X.^#; Gong, Y.^#; Gou, K.; Luo, Y.; Jia, D.; Dai, L.^*; Zhao, Y.^*; Sun, Q.^* Biophysical and biochemical properties of PHGDH revealed by studies on PHGDH inhibitors. Cell Mol Life Sci 2021, 79 (1), 27.

3. Li, C. G.^#;  Zhou, Y.^#;  Xu, J.^#;  Zhou, X.;  Huang, Z. K.;  Zeng, T.;  Yang, X. W.;  Tao, L.;  Gou, K.;  Zhong, X.;  Chen, Q.;  Luo, Y. F.^*; Zhao, Y. L.^*, A novel series of teriflunomide derivatives as orally active inhibitors of human dihydroorotate dehydrogenase for the treatment of colorectal carcinoma. Eur J Med Chem 2022, 238, 14489.

4. Li, C.^#; Zhou, Y.^#; Xu, J.; Zhou, X.; Liu, S.; Huang, Z.; Qiu, Z.; Zeng, T.; Gou, K.; Tao, L.; Zhong, X.; Yang, X.; Zhou, Y.; Su, N.; Chen, Q.; Zhao, Y. L.^*; Luo, Y. F^*. Discovery of potent human dihydroorotate dehydrogenase inhibitors based on a benzophenone scaffold. Eur J Med Chem 2022, 243, 114737.

5. Zhou, Y.; Tao, L.; Zhou, X.; Zuo, Z. P.; Gong, J.; Liu, X. C.; Zhou, Y.; Liu, C. Q.; Sang, N.; Liu, H.; Zou, J.; Gou, K.; Yang, X. W.; Zhao, Y. L.^* DHODH and cancer: promising prospects to be explored. Cancer & Metabolism 2021, 9 (1).

6. Li, C. G.^#; Yang, X. W.^#; Luo, Y.; Liu, H.; Zhong, X.; Zhou, X.; Zeng, T.; Tao, L.; Zhou, Y.; Gou, K.; Yang, X. Y.; Liu, X. C.; Chen, Q.; Zhao, Y. L.^*; Luo, Y. F.^* Design, synthesis, and biological evaluation of a novel series of teriflunomide derivatives as potent human dihydroorotate dehydrogenase inhibitors for malignancy treatment. J Med Chem 2021, 64 (24), 18175-18192.

7. Zhou, Y.^#; Zou, J.^#; Zhong, X.; Xu, J.; Gou, K.; Zhou, X.; Zhou, Y.; Yang, X.; Guan, X.; Zhang, Y.; Chen, D.; Cen, X.; Luo, Y.^*; Zhao, Y.^* Synthesis and biological evaluation of novel pyrazole amides as potent mitochondrial complex I inhibitors. Eur J Med Chem. 2023, 258, 115576.

8. Liu, H.; Wei, J.; Sang, N.; Zhong, X.; Zhou, X.; Yang, X.; Zhang, J.; Zuo, Z.; Zhou, Y.; Yang, S.; Du, J.^*; Zhao, Y.^* The novel LSD1 inhibitor ZY0511 suppresses diffuse large B-cell lymphoma proliferation by inducing apoptosis and autophagy. Med Oncol 2021, 38 (10), 124.

通讯地址：四川省泸州市龙马潭区香林路1段1号西南医科大学药学院药物化学教研室（弘润楼），邮编646000。

E-mail: zhouxia@swmu.edu.cn