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药物分析教研室

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王路军 副教授 (硕士生导师)

发布日期:2022-01-03    作者:     来源:     点击:

王路军,博士,西南医科大学科技处副处长,西南医科大学·泸州产业技术研究院院长,泰国清迈大学兼职博士生导师,药学院副教授,硕士生导师,四川省海外高层次留学人才,四川省科技青年联合会理事,四川省分析测试协会理事,西南医科大学第四届十佳青年创新带头人,西南医科大学青年科技人才特别支持计划项目获得者,西南医科大学优秀员工,西南医科大学本科优秀论文指导教师;担任Chinese Chemical LettersIF=9.1,中国科学院1区)、沈阳药科大学学报以及西南医科大学学报青年编委,是Angewandte Chemie International EditionTrends in Analytical ChemistryChemical Engineering Journal ACS Applied Materials and InterfaceAnalytica Chimica ActaTalantaJournal of chromatography A、《色谱》等杂志的长期审稿专家;目前主持国家自然科学基金、四川省科技厅面上项目、国家重点实验室开放课题、四川省教育厅重点项目以及泸州市科技厅等项目10余项;近年来在Trends in analytical chemistry Chemistry of MaterialsAnalytical Chemistry ACS Applied Materials & InterfacesNanoscaleAnalytica Chimica ActaJournal of chromatography A等高水平杂志上发表SCI论文40余篇,其中以第一通讯作者发表SCI论文30余篇单篇最高影响因子14.908总影响因子300余分,授权或申请国家发明专利8项;获得全国药物分析优秀论文三等奖1项,泸州市五四青年奖章集体1项,西南医科大学“卓越青年学者交流论坛”一等奖1项,泸州市药学会优秀论文二等奖多项。

二 研究方向

1. 基于色谱固定相分离分析的方法学研究,基于新型混合模式、亲水色谱固定相用于中药、环境、化妆品以及临床等实际样本的分离分析;

2. 新型手性固定相材料的创制,将新型智能响应材料、多孔材料等与传统手性拆分剂结合用于对映体的拆分,解决制药工厂、生物工厂等领域面临的实际问题;

3. 聚焦跨学科的发展,将3D打印技术与分析化学以及疾病检测领域融合,开发新型生物标志物、手性传感的新方法与技术;

4. 新型分离分析材料的产业化实践与探索

三 招生专业

1. 药物分析学(学术型硕士)

2. 药学硕士(药物质量控制、专业型硕士)

联系方式:

E-mail: wlj@swmu.edu.cn  

地址:西南医科大学城北校区(泸州市龙马潭区香林路11号)弘润楼428室,邮编 646000

学习及工作经历

2023.12-至今    西南医科大学,科技处副处长

2022.09-2023.12  西南医科大学,校团委副书记(挂职)

2018.12-至 今   西南医科大学,药学院,副教授/副研究员

2020.02-2021.04  捷克中欧技术研究院,博士后,合作教授Martin Pumera

2016.12-2018.11  西南医科大学,药学院,讲师

2011.09-2016.12 重庆大学,化学工程与技术,博士,导师:夏之宁

2007.09-2011.06  湘南学院,药学,学士

兼职/评审工作

1. 西南医科大学司法鉴定中心法医毒物鉴定人

2. 广西壮族自治区/四川省自然科学基金的函评专家

3. 教育部学位与研究生教育发展中心硕士论文评审专家

4. 教育部学位中心本科抽检毕业论文评审专家

5. 企业委托相关科技成果评审专家

6. 各类SCI、中文核心期刊论文长期审稿专家

部分SCI代表性论文(均为第一或通讯作者)

2024

1. Honglin Yang, Bing Guo, Xuemei Dai, Meifang Liao, Jing Ou, Yaxin Yang, Lian Zhong, Yanyu Jiang, Jie Wen, Lujun Wang*. Octadecylamine dendrimers modified silica for novel mixed-mode liquid chromatographic stationary phases, Microchemical Journal. 2024, 197: 109798. (通讯作者,IF=5.304)

2023

1. Meijun Wan, Yunchao Zheng, Xuemei Dai, Honglin Yang, Jingqiu Zhou, Jing Ou, Yaxin Yang, Meifang Liao, Zhining Xia*, Lujun Wang*. Click chemistry for the preparation of β-cyclodextrin grafting uniform spherical covalent organic framework materials for chiral separation, Chemistry of Materials, 2023, 35: 609–616. (通讯作者,IF=10.508TOP期刊)

2. Meijun Wan, Asha Jimu, Honglin Yang, Jingqiu Zhou, Xuemei Dai, Yunchao Zheng, Jing Ou, Yaxin Yang, Jing Liu, Lujun Wang*. MXene quantum dots enhanced 3D-printed electrochemical sensor for the highly sensitive detection of dopamine, Microchemical Journal. 2023, 184: 108180. (通讯作者,IF=5.304)

3. Honglin Yang, Xuemei Dai, Meifang Liao, Jing Ou, Yaxin Yang, Meijun Wan, Jingqiu Zhou, Lujun Wang*. Spherical covalent organic framework and gold nanoparticles modified 3D-printed nanocarbon electrode for the sensor of acetaminophen, Microchemical Journal. 2023, 189: 108547. (通讯作者,IF=5.304)

4. Jingqiu Zhou, Meijun Wan, Xuemei Dai, Honglin Yang, Yaxin Yang, Jing Ou, Meifang Liao, Jing Liu, Lujun Wang*. Polar-embedded phenyl dendritic stationary phase for multi-mode chromatographic separation, Microchemical Journal. 2023, 185: 108303. (通讯作者,IF=5.304)

5. Yaxin Yang, Jingqiu Zhou, Qiaojie Liang, Xuemei Dai, Honglin Yang, Meijun Wan, Jing Ou, Meifang Liao, Lujun Wang*. Comparing the separation performance of poly(ethyleneimine) embedded butyric and octanoic acid based chromatographic stationary phases, Journal of Chromatography A. 2023, 464268. (通讯作者,IF=4.601

2022

1. Lujun Wang, Siowwoon Ng, Jyoti, Martin Pumera*. Al2O3/Covalent Organic Framework on 3D-Printed Nanocarbon Electrodes for Enhanced Biomarker Detection, ACS Applied Nano Materials, 2022, 7: 9719-9727. (第一作者,IF=6.140)

2. Meijun Wan, Jingqiu Zhou, Honglin Yang, Xuemei Dai, Yunchao Zheng, Zhining Xia*, Lujun Wang*. Covalently N-Doped MXene Quantum Dots for Highly Stable Fluorescent Cu2+ Ion Sensor, ACS Applied Nano Materials. 2022, 8: 11715-11722. (第一作者,IF=6.140)

3. Xuemei Dai, Jingqiu Zhou, Honglin Yang, Meijun Wan, Yunchao Zheng, Jing Ou, Yaxin Yang, Meifang Liao, Lujun Wang*. Comparing the chromatographic performance of benzene and aniline end capped stationary phase synthesized by click chemistry, Microchemical Journal. 2022, 181: 107840. (通讯作者,IF=5.304)

4. Qiurong Luo, Meijun Wan, Jingqiu Zhou, Xuemei Dai, Honglin Yang, Fengjiao Zu, Yunchao Zheng, Lujun Wang*. Preparation and evaluation of a double-hydrophilic interaction stationary phase based on bovine serum albumin and graphene quantum dots modified silica, Journal of Chromatography A. 2022, 462933. (通讯作者,IF=4.601

5. Yunchao Zheng, Meijun Wan, Jingqiu Zhou, Xuemei Dai, Honglin Yang, Zhining Xia*, Lujun Wang*. One-pot method for the synthesis of β-cyclodextrin and covalent organic framework functionalized chiral stationary phase with mixed-mode retention mechanism, Journal of Chromatography A. 2022, 1662: 462731. (通讯作者,IF=4.601

6. Jingqiu Zhou, Yaxin Yang, Meijun Wan, Yunchao Zheng, Xuemei Dai, Honglin Yang, Lujun Wang*. Preparation and evaluation of an ionic liquid embedded C18 and cellulose co-functionalized stationary phase with mixed-mode and chiral separation abilities, Microchemical Journal. 2022, 175: 107123. (通讯作者,IF=5.304)

2021

1. Lujun Wang, Wanli Gao, Siowwoon Ng, Martin Pumera*. Chiral Protein–Covalent Organic Framework 3D-Printed Structures as Chiral Biosensors. Analytical Chemistry. 2021, 93: 5277-5283. (第一作者,IF=8.008TOP期刊)

2. Lujun Wang, Martin Pumera. Recent advances of 3D printing in analytical chemistry: focus on microfluidic, separation, and extraction devices, TrAC Trends in Analytical Chemistry, 2021, 135: 116151. (第一作者,IF=14.908TOP期刊)

3. Lujun Wang, Martin Pumera*. Covalently modified enzymatic 3D-printed bioelectrode, Microchimica Acta. 2021, 11: 1-8. (第一作者,IF=6.408)

4. Yunchao Zheng, Meijun Wan, Jingqiu Zhou, Qiurong Luo, Die Gao, Qifeng Fu, Jing Zeng, Fengjiao Zu, Lujun Wang*. Striped covalent organic frameworks modified stationary phase for mixed mode chromatography, Journal of Chromatography A. 2021, 1649: 462186.(通讯作者,IF=4.601

5. Qiurong Luo, Zhirong Zhong, Yunchao Zheng, Die Gao, Zhining Xia*, Lujun Wang*. Preparation and evaluation of a poly(N-isopropylacrylamide) derived graphene quantum dots based hydrophilic interaction and reversed-phase mixed-mode stationary phase for complex sample analysis, Talanta, 2021, 224: 121869. (通讯作者,IF=6.556)

6. Jiayao1, Lyu, Lujun Wang1, Xiaosheng Bai1, Xingjie Du1, Jun Wei, Jianxing Wang, Yan Lin, Zhenyu Chen, Zhongbing Liu, Jianming Wu*, Zhirong Zhong*. Treatment of Rheumatoid Arthritis by Serum Albumin Nanoparticles Coated with Mannose to Target Neutrophils. ACS Applied Materials & Interfaces. 2021, 13: 266-276. (共同一作,IF=10.383TOP期刊)

7. 骆秋蓉,王诗琦,王路军*,二维材料及其量子点在分离科学领域的研究进展,分析测试学报,2021, 40: 1246-1256.

2020

1. Xiujun Ren, Qiurong Luo, Di Zhou, Kailian Zhang, Die Gao, Qifeng Fu, Jun Liu, Zhining Xia*, Lujun Wang*. Thermoresponsive chiral stationary phase functionalized with the copolymer of β-cyclodextrin and N-isopropylacrylamide for high performance liquid chromatography. Journal of Chromatography A. 20201618: 460904.(通讯作者,IF=4.759)

2. Qiurong Luo, Xiujun Ren, Siping Wei, Yunchao Zheng, Die Gao, Qifeng Fu, Zhining Xia, Lujun Wang*. Preparation and evaluation of a molybdenum disulfide quantum dots embedded C18 mixed-mode chromatographic stationary phase. Analytical and Bioanalytical Chemistry. 2020, 415: 1365-1374. (通讯作者,IF=4.142)

3.Di Zhou, Yunchao Zheng, Qiurong Luo, Die Gao, Qifeng Fu, Kailian Zhang, Zhining Xia*, Lujun Wang*. Preparation of an aspartame and N-isopropyl acrylamide copolymer functionalized stationary phase with multi-mode and chiral separation abilities. Journal of Chromatography A, 2020, 1634: 461675.(通讯作者,IF=4.759)

4. Jingqiu Zhou, Xiujun Ren, Qiurong Luo, Die Gao, Qifeng Fu, Di Zhou, Fengjiao Zu, Zhining Xia, Lujun Wang*. Ionic liquid functionalized β-cyclodextrin and C18 mixed-mode stationary phase with achiral and chiral separation functions. Journal of Chromatography A, 2020, 1634: 461674. (通讯作者,IF=4.759)

5. Meijun Wan, Qiurong Luo, Xiujun Ren, Yunchao Zheng, Die Gao, Qifeng Fu, Fengjiao Zu, Zhining Xia, Lujun Wang*. Preparation and performance of a poly (ethyleneimine) embedded N-acetyl-L-phenylalanine mixed-mode stationary phase for HPLC. Microchemical Journal, 2020, 157: 105021. (通讯作者,IF=4.821)

6. Fengjiao Zu, Zhongwen Qian, Feng Li, Xiujun Ren, Qiurong Luo, Die Gao, Di Zhou, Kailian Zhang, Zhining Xia, Lujun Wang*. Poly (ethyleneimine) embedded octadecyl based stationary phase for multimodal chromatographic separation, Microchemical Journal, 2020, 156: 104917. (通讯作者,IF=4.821) 

7. Di Zhou, Qiurong Luo, Qin Zeng, Yunchao Zheng, Xiujun Ren, Die Gao, Qifeng Fu, Kailian Zhang*, Zhining Xia, Lujun Wang*. Preparation of an aminophenylboronic acid and N-isopropyl acrylamide copolymer functionalized stationary phase for mixed-mode chromatography, Journal of Chromatography A, 2020, 1627: 461423. (通讯作者,IF=4.759)

8. Youping Yi1, Lujun Wang1, Lin Chen1, Yan Lin1, Zhongling Luo, Zhenyu Chen, Ting Li, Jianming Wu, Zhirong Zhong*. Farnesal-loaded pH-sensitive polymeric micelles provided effective prevention and treatment on dental caries, Journal of Nanobiotechnology, 2020, 18: 1-16. (共同第一作者,IF=10.435)

2019以前

1. Lujun Wang, Weili Wei*, Zhining Xia*, Xu Jie, Zeng Zilu Xia. Recent advances in materials for stationary phases of mixed-mode High-Performance Liquid Chromatography. Trends in analytical chemistry. 2016, 80: 495-506. (第一作者IF=12.296, TOP期刊)

2. Xiujun Ren, Chengxia Hu, Die Gao, Qifeng Fu, Kailian Zhang, Fengjiao Zu*, Jing Zeng, Lujun Wang, Zhining Xia. Preparation of a poly(ethyleneimine) embedded phenyl stationary phase for mixed-mode liquid chromatography.Analytica Chimica Acta. 2018, 1042: 165-173. (通讯作者,IF=5.256)

3. Xiujun Ren, Kailian Zhang, Die Gao, Qifeng Fu, Jing Zeng, Di Zhou, Lujun Wang*, Zhining Xia. Mixed-mode liquid chromatography with a stationary phase co-functionalized with ionic liquid embedded C18 and an aryl sulfonate group. Journal of Chromatography A. 2018, 1564: 137-144. (通讯作者,IF=3.981)

4. Di Zhou, Jing Zeng, Qifeng Fu, Die Gao, Kailian Zhang, Xiujun Ren, Kai Zhou, Zhining Xia, Lujun Wang*. Preparation and evaluation of a reversed-phase/hydrophilic interaction/ion-exchange mixed-mode chromatographic stationary phase functionalized with dopamine-based dendrimers. Journal of Chromatography A. 2018, 1571: 165-175. (通讯作者,IF=3.981)

5. Lujun Wang*, Die Gao, Qifeng Fu, Kai Zhou, Zhining Xia*. Bioactivity-guided isolation of antioxidant compounds from Pouzolzia zeylanica (L.) benn.Pharmacognosy Magazine. 2018, 14: 444-450. (第一作者+通讯作者, IF=1.525)

6. Lujun Wang, Die Gao, Zelong Xu, Fengqing Yang, Zhining Xia*. Chemical constituents from Pouzolzia zeylanica with PPARγ and PPARβ activities. Chemistry of natural compounds. 2015, 51: 995-997. (第一作者,IF=0.473)

申请授权发明专利

1.王路军等,一种智能响应液相色谱填料及其制备方法,中国,发明专利号:ZL201610024218.X(已经授权)

2.王路军等,一种手性选择性可切换的高效液相色谱填料及其制备方法,中国发明专利号:ZL201610023376.3(已经授权)

3.王路军等,一种基于环糊精的智能响应手性色谱填料及其制备方法和应用,发明专利,专利号:ZL 201910399510. 3(已经授权)

4.王路军等,一种多齿化氨基极性内嵌型混合模式高效液相色谱填料及其制备方法和应用,发明专利,专利号:ZL201810796409.7(已经授权)

5.王路军等,一种聚(N-异丙基丙烯酰胺)修饰石墨烯量子点的色谱填料及其制备方法和应用,发明专利,专利号:ZL202010711120.8(已经授权)

主持科研项目

1.国家自然科学基金青年科学基金项目21804112,50万(+匹配经费),2019/01-2021/12,结题,主持。

2.四川省科技厅面上项目2022NSFC062240万,2022/1-2023/12,在研,主持。

3. 省部共建药用资源化学与药物分子工程国家重点实验室开放课题,4万,结题,主持。

4. 四川省教育厅重点项目,18ZA0527,4万,2018/1-2020/12,结题,主持。

5. 泸州市科技局项目,05/00160096,8万,2022/1-2023/12在研,主持。

6. 西南医科大学面上项目,2021ZKMS043,10万,2022/1-2023/12,在研,主持。

7. 西南医科大学青年基金项目,2017-ZRQN-118,1万,2018/1-2019/12,结题,主持。

8. 西南医科大学青年科技人才培育计划项目,10万,2020-2022,在研,主持。

9. 西南医科大学人才启动经费,2017/01-2019/12,结题,主持。

学生培养

1. 邓琴敏等,电感立方——医药领域3D打印系列电极传感产品开拓者,第九届四川省国际“互联网+”大学生创新创业大赛铜奖,第一指导教师

2. 羊洪林、廖美芳、万美君、于馨雅、杜析壕、罗茂文、段溢潞、段溢濂,3D打印系列电极产品的制备及其传感应用,第十七届“挑战杯”四川省大学生课外学术科技作品竞赛三等奖,第一指导教师

3. 代雪梅、万美君、周静秋、欧静、杨亚欣、李贞亿、林晓金、尔古鲁洪,混合模式液相色谱产品的“点击”制备及其应用,第十七届“挑战杯”四川省大学生课外学术科技作品竞赛三等奖,第一指导教师

4. 郭宝仪、王笛胡、霍纪然、蓝澜、罗徐、郝思捷、杨婷、王清清、白杨、程光晖,观酒城发展新颜建两州振兴新言,第十七届“挑战杯”四川省大学生课外学术科技作品竞赛红色专项活动三等奖,第一指导教师

5. 以第一指导教师指导大学生创新创业项目6项,其中国家级1项省级4项,校级1项;

6. 毕业硕士6名(其中2人获得国家奖学金);

7. 指导本科毕业论文18篇,其中,校级优秀毕业论文2篇,本科生以第一作者发表SCI论文8篇。