微生物与生化药学教研室-郭秀蓉副教授

郭秀蓉，女，出生于1987年11月，2016年获四川大学博士学位，德国明斯特纳米技术研究中心博士后，现任西南医科大学药学院副研究员。主要从事核苷和核酸合成及其超分子化学和纳米材料方面的性质研究，致力于功能化核苷和核苷酸，累计发表SCI论文20余篇 。

学习及工作经历 

2019.09-至今   西南医科大学药学院 副研究员

2019.09-2021.12  西南医科大学药学院 讲师

2018.09-2019.08  成都先导药物开发股份有限公司 高级研发

2016.07-2018.01      德国明斯特纳米技术研究中心  博士后

2014.09-2016.06      德国奥斯纳布吕克大学  博士研究生(联合培养)

2013.09-2016.06      四川大学  博士学位

2009.09-2013.06      四川大学  硕士学位

2005.09-2009.06      乐山师范学院  学士学位

联系方式：

E-mail：xiurongguo@hotmail.com

地址：泸州市龙马潭区香林路1段1号西南医科大学城北校区 弘润楼425

近三年承担及参与的科研项目：

1. 泸州市人民政府-西南医科大学科技战略合作项目，2020LZXNYDJ36，离子响应自组装凝胶体系构建及细胞培养中应用研究，2020.11.01-2023.10.31, 10万元，在研，主持

2. 泸州市人才引进专项，0903-00041036， 2019.01.01-2022.12.30，300万元，在研，参与

代表性论文

1. Xiurong Guo^#, Nan Tang^#, Hui Lei, Qi Fang, Li Liu, Quan, Zhou, Can Song*. Metagenomic analysis of antibiotic resistance genes in untreated wastewater from three different hospitals. Front. in Microbiol., 2021, 12:709051

2. Xiurong Guo, Hui Lei, Kailian Zhang, Famin Ke, Can Song*. Diversification of animal gut microbes and NRPS gene clusters in some carnivores, herbivores and omnivores. Biotechnology & Biotechnological Equipment, 2020, 34, 1280-1287.

3. Yingying Chai^#，Peter Leonard^#, Xiurong Guo^#, Frank Seela, Silver-Mediated Homochiral and Heterochiral α-dC/β-dC Base Pairs: Synthesis of α-dC through Glycosylation and Impact of Consecutive, Isolated, and Multiple Metal Ion Pairs on DNA Stability, Chem. Eur. J. 2019, 25, 16639 – 16651.

4. Xiurong Guo, Frank Seela*, Anomeric 2’-Deoxycytidines and Silver Ions: Hybrid Base Pairs with Greatly Enhanced Stability and Efficient DNA Mismatch Detection with α-dC. Chem. Eur. J. 2017, 23, 11776-11779.

5. Xiurong Guo^#, Peter Leonard^#, Sachin A. Ingale^#, Jiang Liu, Hui Mei, Martha Sieg, Frank Seela*. 5-Aza-7-deaza-2’-deoxyguanosine and 2'-Deoxycytidine form Programmable Silver-Mediated Base Pairs with Metal Ions in the Core of the DNA Double Helix. Chem. Eur. J. 2018, 24, 8883-8892.

6. Xiurong Guo^#, Peter Leonar^#, Sachin A. Ingale^#, Frank Seela*. Gemcitabine, Pyrrologemcitabine and 2’-Fluoro- 2’-Deoxycytidines: Synthesis, Physical Properties and Impact of Sugar Fluorination on Silver Ion Mediated Base Pairing. Chem. Eur. J. 2017, 23, 17740-17754.

7. Xiurong Guo, Sachin A. Ingale, Haozhe Yang, Yang He, Frank Seela, MercuryII-mediated base pairs in DNA: unexpected behavior in metal ion binding and duplex stability induced by 2'-deoxyuridine 5-substituents. Org. Biomol. Chem. 2017, 15, 870-883.

8. Xiurong Guo, Guang Xin, Shiliang He, Yanyan Wang, Baozhan Huang, Hang Zhao, Zhihua Xing, Qianming Chen*, Wen Huang, Yang He*, Novel organic gelators based on pentose derivatized diosgenyl saponins. Org. Biomol. Chem, 2013, 11, 821-827.

9. Shiliang He^#, Hang Zhao^#, Xiurong Guo^#, Xiaoping Xu, Xinglong Zhou, Jiang Liu, Zhihua Xing, Ling Ye, Lu Jiang, Qianming Chen, Yang He. The readout of base-pair information in adenine-thymine α-D-Arabinonucleosides. Chem. Eur. J. 2014, 20, 15473-15481.

10. Hang Zhao^#, Xiurong Guo^#, Shiliang He^#, Xin Zeng, Xinglong Zhou, Chaoliang Zhang, Jing Hu, Xiaohua Wu, Zhihua Xing, Liangyin Chu, Yang He* and Qianming Chen*. Complex morphogenesis of pyrimido[4,5-d]pyrimidine nucleoside supramolecular structures. Nat. Commun. 2014, DOI: 10.1038/ncomms4108.

11. Shiliang He^#, Hang Zhao^#, Xiurong Guo^#, Guang Xin, Baozhan Huang, Limei Ma, Xinglong Zhou, Rui Zhang, Dan Du, Xiaohua Wu, Zhihua Xing,Wen Huang*, Qianming Chen*, Yang He*, Supramolecular organogelators based on Janus type AT nucleosides. Tetrahedron, 2013, 69, 9245-9251.

12. Yuchen Jiang，Hui Feng, Yuchun Lin*, Xiurong Guo*. New strategies against drug resistance to herpes simplex virus. Int. J. Oral. Sci. 2016, 8,1-6.