宋璨（1989-），男，博士，农工党党员，四川仪陇人。2013年6月于西南大学获微生物与生化药学硕士学位，2017年6月于重庆大学获生物医学工程学博士学位，2017年7月起在西南医科大学药学院从事教学及科研工作。中国生物物理学会（肠道菌群分会）会员，中国菌物学会会员，中华中医药学会会员。农工党西南医科大学基层委员会副主委、第一支部主委，农工党泸州市委会科技专委会副主任。
主要研究方向：
药用多糖导向的肠道微生态工程与转化
医用生物（大）分子的创制与临床转化
联系方式：
邮箱：cansong@swmu.edu.cn
地址：西南医科大学城北校区弘润楼426室
SCI代表论文（第一或通讯）：
(21) Zhang Qifan#, Deng Huiling#, Guo Xiurong, Su Min, Wu Nannan, Song Yunbo, Liu Qiuyu, Fu Aimin, Song Can*. Prebiotic potential of Polygonatum sibiricum Red. leaf polysaccharides in regulating gut microbiota to alleviate antibiotic-associated diarrhea, Polish Journal of Food and Nutrition Sciences, 2026, 76: 288–300.（JCR 2区，IF:2.3）
(20) Deng Jiasong#, Ke Famin#, Li Yumeng, You Xingyue, Liu Qiuyu, Chen Rui, Song Can*, Guo Xiurong*. A Novel Silver(I)-Acyclocytidine Complex with Unique Coordination Mode and Enhanced Antibacterial Activity, Applied Organometallic Chemistry, 2026, 40: e70598.（中国科学院2区，IF:4.1）
(19) Tang Mengqi#, Yu Hailun#, Deng Jiasong, Ke Famin, Liu Qiuyu, Xu Maohan, Tian Xueyi, Wang Junjie, Song Can*, Guo Xiurong*. Enhancing the antibacterial effect of silver Ions by a cholesterol -2'-deoxycytidine conjugate against Escherichia coli and Staphylococcus aureus, ChemistrySelect, 2026, 11: e01427.
(18) Ma Linhua, Zhang Qifan, Lai Yong, Long Xiao, Wang Fang, Feng Bimin, Guo Xiurong, Liu Qiuyu, Song Can*. The sulfated modification of polysaccharide from Poria cocos and its probiotic properties on gut microbiota, Journal of the Science of Food and Agriculture, 2025, 14: 7853–7867.（JCR 1区，IF:3.5）
(17) Lai Yong#, Zhang Qifan#, Xu Maohan, Guo Xiurong, Zhou Quan, Liu Qiuyu, Deng Huiling*, Song Can*. Restoration of antibiotic associated diarrhea induced gut microbiota disorder by using Dictyophora indusiata water-insoluble polysaccharides in C57BL/6J mice, Frontiers in Nutrition, 2025, 12: 1607365. （JCR 1区，IF:5.1）
(16) Lai Yong, Deng Huiling, Fang Qi, Ma Linhua, Lei Hui, Guo Xiurong, Chen Ya, Song Can*. Water-insoluble polysaccharide extracted from Poria cocos alleviates antibiotic-associated diarrhea based on regulating the gut microbiota in mice, Foods, 2023,12: 3080.（JCR 1区，IF:5.2）
(15) Lai Yong#, Deng Huiling#, Chen Meiya, Fan Chunhua, Chen Ya, Wang Fang, Zhou Quan, Song Can*. In vitro fermentation properties of grape seed polysaccharides and the effect on regulating gut microbiota in mice, Journal of Food Measurement and Characterization, 2023, 17: 5506–5517.（JCR 2区，IF:3.4）
(14) Fang Qi #, Lai Yong#, Zhang Dan, Lei Hui, Wang Fang, Guo Xiurong, Song Can*. Gut microbiota regulation and prebiotic properties of polysaccharides from Oudemansiella raphanipes mushroom, World Journal of Microbiology and Biotechnology, 2023, 39: 167.（JCR 2区，IF:4.2）
(13) Lai Yong, Fang Qi, Guo Xiurong, Lei Hui, Zhou Quan, Wu Nannan, Song Can*. Effect of polysaccharides from Dictyophora indusiata on regulating gut microbiota and short-chain fatty acids in mice, Journal of Food Measurement and Characterization, 2023, 17: 1-11.（JCR 2区，IF:3.1）
(12) Wang Rui#, Lai Yong#, Fang Qi, Chen Meiya, Lei Hui, Song Can*. Discovery of enzymes to bio-transform ginsenoside Rd into ginsenosides F2 and CK using metagenomics and genomic mining, Archives of Microbiology, 2022, 204: 694.
(11) Lai Yong#, Yu Hailun#, Deng Huiling, Fang Qi, Lei Hui, Liu Li, Wu Nannan, Guo Xiurong*, Song Can*. Three main metabolites from Wolfiporia cocos (F.A. Wolf) Ryvarden & Gilb. regulate the gut microbiota in mice: A comparative study using Microbiome-Metabolomics, Frontiers in Pharmacology, 2022, 13: 911140.（JCR 1区，IF:5.9）
(10) Luo Yu#, Fang Qi#, Lai Yong, Lei Hui, Zhang Dan, Niu Hong, Wang Rui, Song Can*. Polysaccharides from the leaves of Polygonatum sibiricum Red. regulate the gut microbiota and affect the production of short-chain fatty acids in mice, AMB Express, 2022, 12: 35.（JCR 2区，IF:4.1）
(9) Luo Yu, Fang Qi, Lai Yong, Niu Hong, Wang Rui, Song Can*. High-throughput sequencing technology reveals polysaccharides from Angelica dahurica that affect gut microbiota in mice, Biotechnology & Biotechnological Equipment, 2022, 35: 1280-1287.
(8) Song Can#, Huang Feihong#, Liu Linyu, Zhou Quan, Zhang Dan, Fang Qi, Lei Hui*, Niu Hong*. Characterization and prebiotic properties of pectin polysaccharide from Clausena lansium (Lour.) Skeels, International Journal of Biological Macromolecules, 2022, 194: 412-421.（中国科学院1区，Top期刊，IF:8.0）
(7) Luo Yu, Lei Hui, Wang Rui, Zhao Hai, Zhang Guohua*, Song Can*. A novel in vivo functional screening method for the candidate polyphosphate accumulating organisms isolation, Applied Biochemistry and Microbiology, 2021, 57: S71-S77.
(6) Guo Xiurong#, Tang Nan#, Lei Hui, Fang Qi, Liu Li, Zhou Quan, Song Can*. Metagenomic analysis of antibiotic resistance genes in untreated wastewater from three different hospitals, Frontiers in Microbiology, 2021, 12: 709051.（JCR 1区，IF: 5.6）
(5) Cheng Xi, Guo Xiurong, Huang Feihong, Lei Hui, Zhou Quan, Song Can*. Effect of different sweeteners on the oral microbiota and immune system of Sprague Dawley rats, AMB Express, 2021, 11: 8.
(4) Guo Xiurong, Lei Hui, Zhang Kailian, Ke Famin, Song Can*. Diversification of animal gut microbes and NRPS gene clusters in some carnivores, herbivores and omnivores, Biotechnology & Biotechnological Equipment, 2020, 34: 1280-1287.
(3) Cheng Xi, Huang Feihong, Zhang Kailian, Yuan Xiaoping*, Song Can*. Effects of none-steroidal anti-inflammatory and antibiotic drugs on the oral immune system and oral microbial composition in rats, Biochemical and Biophysical Research Communications, 2018, 507: 420-425.
(2) Song Can, Wang Bochu*, Tan Jun*, Zhu Liancai, Lou Deshuai. Discovery of tauroursodeoxycholic acid biotransformation enzymes from the gut microbiome of black bears using metagenomics. Scientific Reports. 2017, 7: 45495.
(1) Song Can, Wang Bochu*, Tan Jun*, Zhu Liancai, Lou Deshuai, Cen Xiaoxi. Comparative analysis of the gut microbiota of black bears in China using high-throughput sequencing, Molecular Genetics and Genomics. 2017, 292: 407-414.
发明专利：
1. 宋璨；方琪；赖勇；一种黑皮鸡枞菌多糖及其制备方法与应用, 2023-2-20, 中国, CN202310134592.5.（授权）
2. 宋璨；王瑞；方琪；雷辉；刘莉；一种密码子优化的糖苷酶SWMU-F2-2及其制备方法与应用, 2021-12-31, 中国, CN202111137767.5.（授权）
3. 祝连彩；王伯初；宋璨；娄德帅；季顺林；新的7α-羟基类固醇脱氢酶基因S1-a-1, 2017-1-5, 中国, CN201710008510.7.（授权）
4. 王伯初；宋璨；祝连彩；季顺林；娄德帅；新的7α-羟基类固醇脱氢酶基因S1-a-2, 2017-1-5, 中国, CN201710008509.4.（授权）
5. 王伯初；宋璨；祝连彩；娄德帅；张智；新的7β-羟基类固醇脱氢酶基因Y1-b-1, 2017-1-5, 中国, CN201710008588.9.（授权）
6. 王伯初；宋璨；祝连彩；季顺林；娄德帅；新的7α-羟基类固醇脱氢酶基因Y1-a-1, 2017-1-5, 中国, CN201710008586.X.（授权）
