宋璨(1989-),男,农工党员,农工党西南医科大学基层委员会第一支部副主委,四川仪陇人。2017年6月于重庆大学获生物医学工程学博士学位,2017年7月起在西南医科大学药学院从事教学及科研工作。
研究方向:
植物及真菌多糖调控肠道微生态的机制研究与益生元开发
基于生物大分子的创口组织工程修复与新型生物医药开发
肠道微生物基因组中新颖酶挖掘及药物生物转化制备
学习及工作经历:
2017.07-至今 西南医科大学,药学院,讲师
2013.07-2017.06 重庆大学,生物工程学院,博士
联系方式:
邮箱:cansong@swmu.edu.cn
地址:西南医科大学忠山校区含光楼223室
学生指导与社会服务:
西南医科大学大学生创新创业项目“浴足良方”暨西南医科大学入园学生企业良方保健中心学术指导老师。
西南医科大学大学生创新创业项目“益启传媒”暨西南医科大学入园学生企业泸州益启传媒有限责任公司指导老师。
SCI代表论文(第一或通讯):
(1) Cheng Xi; Guo Xiurong; Huang Feihong; Lei Hui; Zhou Quan; Song Can*; Effect of different sweeteners on the oral microbiota and immune system of Sprague Dawley rats, AMB Express, 2021, 11: 8.
(2) Guo Xiurong; Lei Hui; Zhang Kailian; Ke Famin; Song Can*; Diversification of animal gut microbes and NRPS gene clusters in some carnivores, herbivores and omnivores, Biotechnology & Biotechnological Equipment, 2020, 34: 1280–1287.
(3) Cheng Xi; Huang Feihong; Zhang Kailian; Yuan Xiaoping*; Song Can*; Effects of none-steroidal anti-inflammatory and antibiotic drugs on the oral immune system and oral microbial composition in rats, Biochemical and Biophysical Research Communications, 2018, 507: 420-425.
(4) Song Can; Wang Bochu*; Tan Jun*; Zhu Liancai; Lou Deshuai; Discovery of tauroursodeoxycholic acid biotransformation enzymes from the gut microbiome of black bears using metagenomics, Scientific Reports, 2017, 7: 45495.
(5) Song Can; Wang Bochu*; Tan Jun*; Zhu Liancai; Lou Deshuai; Cen Xiaoxi; Comparative analysis of the gut microbiota of black bears in China using high-throughput sequencing, Molecular Genetics and Genomics, 2017, 292: 407-414.
参与SCI论文:
(6) Lei Hui; Niu Hong; Song Can; Fu Xiujuan; Luo Yu; Chen Siwei; Zhang Dan*; Chlorinated benzophenone derivatives as chemotaxonomic markers for the genus of Pestalotiopsis, Biochemical Systematics and Ecology, 2020, 91: 1-3.
(7) Lei Hui; Zhang Dan; Ding Nan; Chen Siwei; Song Can; Luo Yu; Fu Xiujuan; Bi Xiaoxu*; Niu Hong*; New cytotoxic natural products from the marine sponge-derived fungus Pestalotiopsis sp. By epigenetic modification, RSC Advances, 2020, 10: 37982-37988.
(8) Li Yuhua; Wang Sheng; Sun Yang; Zheng Hongnan; Tang Yuan; Gao Xiaowei; Song Can; Liu Jiayun; Long Yin; Liu Li; Mei Qibing*; Apple polysaccharide could promote the growth of Bifidobacterium longum, International Journal of Biological Macromolecules, 2020, 152: 1186-1193.
(9) Li Yuhua; Xu Wenqi; Sun Yang; Wang Yan; Tang Yuan; Li Yunhua; Gao Xiaowei; Song Can; Liu Li; Mei Qibing*; Modified apple polysaccharide regulates microbial dysbiosis to suppress high-fat diet-induced obesity in C57BL/6J mice, European journal of Nutrition, 2020, 59: 2025-2037.
(10) Li Yuhu; Wang Sheng; Sun Yang; Xu Wenqi; Zheng Hongnan; Wang Yan; Tang Yuan; Gao Xiaowei; Song Can; Long Yin; Liu Jiayun; Liu Li; Mei Qibing*; Apple polysaccharide protects ICR mice against colitis associated colorectal cancer through the regulation of microbial dysbiosis, Carbohydrate Polymers, 2020, 230: 115726.
(11) Lei Hui; Lei Jing; Zhou Xuefeng; Hu Mei; Niu Hong; Song Can; Chen Siwei; Liu Yonghong*; Zhang Dan*; Cytotoxic Polyketides from the Marine Sponge-Derived Fungus Pestalotiopsis heterocornis XWS03F09, Molecules, 2019, 24: 655.
申请专利:
祝连彩;王伯初;宋璨;娄德帅;季顺林;新的7α-羟基类固醇脱氢酶基因S1-a-1, 2017-1-5, 中国, CN201710008510.7.(授权)
王伯初;宋璨;祝连彩;季顺林;娄德帅;新的7α-羟基类固醇脱氢酶基因S1-a-2, 2017-1-5, 中国, CN201710008509.4.(授权)
王伯初;宋璨;祝连彩;娄德帅;张智;新的7β-羟基类固醇脱氢酶基因Y1-b-1, 2017-1-5, 中国, CN201710008588.9.(授权)
王伯初;宋璨;祝连彩;季顺林;娄德帅;新的7α-羟基类固醇脱氢酶基因Y1-a-1, 2017-1-5, 中国, CN201710008586.X.(授权)
主持科研、教学项目:
1. 泸州市人民政府-西南医科大学科技战略合作应用基础研究项目,基于动物肠道微生物组的新型糖苷酶挖掘及其在稀有人参皂苷生物转化的应用基础研究,2020LZXNYDJ28,2020.11.-2023.10,10万元,在研,主持;
2. 校级教改课题“《生物技术制药》综合实验的探索与实践”,JG201946,2020.1.-2021.12,3000元,在研,主持;
3. 西南医科大学青年基金项目,赶黄草内生真菌鉴定及产生活性药物天然产物的评估,2017-ZRQN-100,2018.1.-2020.12,1万元,在研,主持;
参与科研项目:
4. 泸州市人才引进专项,乳酸乳球菌中分泌表达及表面展示植酸酶PhyL并探索其作为新型饲料添加剂的应用研究,0903-00041036,2019. 1.-2022.12,300万元,在研,参与;
5. 科技部“重大新药创制”科技重大专项,体外培育熊胆粉关键技术及临床前研究,2014ZX09301306007,2014.1.-2016.12,200万元,已结题,参与。