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景沛 副研究员 (硕士生导师)

发布日期:2021-05-20    作者:景沛     来源:     点击:

景沛,男,1989年生,博士,副研究员。2021年毕业于四川大学,现工作于西南医科大学附属医院药学部,承担临床药学相关的教学和科研工作。四川省纳米药物专委会委员。2025年度入选西南医科大学附属医院优秀中青年人才库。

主持四川省科学技术厅、泸州市科学技术和人才工作局等各级各类项目7项。以第一/通讯作者身份在ACS Nano, Biomaterials, Chemical Engineering Journal, Journal of Controlled Release等国内外权威刊物发表SCI检索论文17余篇,其中中国科学院一区9篇,影响因子>105篇,最高影响因子17.1,累计影响因子约130。授权国家及国际发明专利2项。作为指导老师,立项大学生创新训练计划项目5项,其中国家级1项,省级2项,校级2项。

研究方向:功能性小分子组装体的设计与制备、药物/蛋白质/基因递送的生物材料技术及机制、机体免疫定向调节等方面的研究。

代表性论文:

1. 基于抗氧化策略的纳米材料在肝纤维化治疗中的潜力与挑战。中国医院药学杂志2025, 45(10), 1192-1197.北大中文核心

2. Injectable hydrogel to deliver bone mesenchymal stem cells preloaded with azithromycin to promotespinal cord repair. ACS Nano, 2024, 18(12), 8934-8951. (中国科学院1区,If: 17.1)

3. Natural polyphenol-loaded cross-linked lipoic acid vesicles treat triple-negative breast cancer by cancer cell killing and metastasis inhibition. Materials & Design, 2023, 236, 112461. (中国科学院1区,If: 8.4)

4. An oligomeric hyaluronic acid-GX1 molecular target drug with polyvalent targeting to CD44 and VEGF receptors. Biomaterials Advances, 2023, 144, 213217. (中国科学院1区,If: 8.457)

5. Aspirin-loaded cross-linked lipoic acid nanodrug prevents postoperative tumor recurrence by residual cancer cell killing and inflammatory microenvironment improvement. Bioconjugate Chemistry, 2023, 34(2), 366-376. (中国科学院2区,If: 6.069)

6. Nanoparticles that target the mitochondria of tumor cells to restore oxygen supply for photodynamic therapy: Design and preclinical validation against breast cancer. Journal of Controlled Release, 2023, 362, 356-370. (中国科学院1区,If: 10.8)

7. Cross-linked lipoic acid nanocapsules serve as H2O2 amplifier to strengthen the H2O2-sensitive prodrug activation. Science China Chemistry, 2023, 66 (9), 2654-2663. (中国科学院1区,If: 9.6)

8. Biomineral-binding liposomes with dual antibacterial effects for preventing and treating dental caries. Biomaterials Science, 2023, 11, 5984-6000. (中国科学院2区,If: 6.6)

9. Nanocomposite hydrogel to deliver the immunomodulator lenalidomide and anti-inflammatory hesperidin locally to joints affected by rheumatoid arthritis. Chemical Engineering Journal, 2023, 476, 146270. (中国科学院1区,If: 15.1)

10. Nanoformulated metformin enhanced the treatment of spinal cord injury. Chemical Engineering Journal, 2022, 446, 137227. (中国科学院1区,If: 13.273)

11. CAQK modification enhances the targeted accumulation of metformin-loaded nanoparticles in rats with spinal cord injury. Nanomedicine: Nanotechnology, Biology and Medicine, 2022, 41, 102526. 中国科学院2区,If: 6.458

12. “One-Stitch” Bioorthogonal Prodrug Activation Based on Cross-Linked Lipoic Acid Nanocapsules. Biomaterials, 2021, 273, 120823. (中国科学院1区,If: 10.317)

13. Enhanced growth inhibition of prostate cancer in vitro and in vivo by a recombinant adenovirus-mediated dual-aptamer modified drug delivery system. Cancer Letters, 2016, 383, 230-242. (中国科学院1If: 5.992)

代表性科研项目:

1. 四川省科学技术厅,2023NSFSC16912023-012024-12,主持

2. 泸州市科学技术和人才工作局,2023LZXNYDJ0082023-102026-09,主持

3. 武当特色中药研究湖北省重点实验室,重点项目,WDCM20240042024-062026-05,主持

4. 医学影像四川省重点实验室,MIKL2025092025-102027-09,主持

5. 西南医科大学,2023QN0892023-112025-10,主持

6. 西南医科大学附属医院,210362021-102024-09主持

单位:西南医科大学附属医院药学部/西南医科大学药学院临床药学教研室

E-mailjingpei.09@swmu.edu.cn